CSIR-Central Scientific Instruments Organization, Chandigarh 160030, India.
DAV University, Jalandhar 144012, Punjab, India.
J Nanosci Nanotechnol. 2019 Feb 1;19(2):646-654. doi: 10.1166/jnn.2019.15402.
Metal organic frameworks (MOFs), MIL-101-Fe (Materials of Institute Lavoisier), have been synthesized by solvothermal method. The as-synthesized MIL-101-Fe particles are observed to have hexagonal shaped morphology with average particle size ranging from 480 to 500 nm. The functionalization of the surface of as-synthesized MIL-101-Fe particles was done with the integration of amine group into the framework to facilitate the conjugation of the drug and other entities. Further, the drug conjugated MOF particles were coated with polyethyleneglycol (PEG) layer so as to extend the drug release time by controlling the faster pH mediated MOF degradation in biological buffers. pH dependent drug release study of the MOF particles was carried out at 3 different pH values, i.e., 5, 6 and 7.4. The drug release profiles showed that the drug released from NH₂-MIL-101-Fe takes less time which was further increased after coating the NH₂-MIL-101-Fe with polyethyleneglycol (PEG@Drug@NH₂-MIL-101-Fe). This confirmed that PEG coated particles have great stability for drug delivery application.
金属有机骨架（MOFs），MIL-101-Fe（ Materials of Institute Lavoisier），是通过溶剂热法合成的。所合成的 MIL-101-Fe 颗粒具有六方形状的形态，平均粒径范围为 480 至 500nm。通过将氨基整合到框架中对合成的 MIL-101-Fe 颗粒的表面进行功能化，以促进药物和其他实体的共轭。此外，将药物共轭的 MOF 颗粒用聚乙二醇（PEG）层进行涂层，以通过控制在生物缓冲液中更快的 pH 介导的 MOF 降解来延长药物释放时间。在 3 个不同的 pH 值（即 5、6 和 7.4）下进行了 MOF 颗粒的 pH 依赖性药物释放研究。药物释放曲线表明，NH₂-MIL-101-Fe 释放药物的时间更短，在 NH₂-MIL-101-Fe 上涂覆聚乙二醇（PEG@Drug@NH₂-MIL-101-Fe）后，释放时间进一步延长。这证实了涂覆有 PEG 的颗粒在药物输送应用中具有很好的稳定性。
