Al Haydar Muder, Abid Hussein Rasool, Sunderland Bruce, Wang Shaobin
Pharmaceutics Department, College of the Pharmacy, University of Kerbala, Kerbala, Iraq.
Pharmaceutics Department, School of Pharmacy, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Drug Des Devel Ther. 2017 Sep 11;11:2685-2695. doi: 10.2147/DDDT.S145716. eCollection 2017.
Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible.
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery.
A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile.
The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively.
The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release.
在过去十年中，金属有机框架材料（MOFs）因其合适的孔径、大表面积和高孔隙率而备受关注。开发如MIL家族这类具有生物相容性的MOFs作为药物递送系统是可行的。
氟比洛芬（FBP）是一种非甾体抗炎药，在水溶液中几乎不溶，因此需要合适的药物递送系统。合成了不同的生物相容性MOFs，如钙基金属有机框架（Ca-MOF）和铁基金属有机框架（Fe-MILs，包括MIL-53、MIL-100和MIL-101），并将其用于FBP的递送。
将50mg每种MOF样品与10mL含5mg FBP的乙腈（40%）在密封容器中混合并搅拌24小时。混合物离心后的上清液通过高效液相色谱法进行分析，以确定FBP在MOF上的负载量。对混合物离心后过夜干燥的固体材料，使用X射线衍射、傅里叶变换红外光谱、扫描电子显微镜、核磁共振和FBP释放曲线分析其负载百分比。
FBP在Ca-MOF、Fe-MIL-53、Fe-MIL-101和Fe-MIL-100上的负载值分别达到10.0%±1%、20%±0.8%、37%±2.3%和46%±3.1%。在pH 7.4的磷酸盐缓冲溶液中研究了FBP的释放曲线。2天后，Ca-MOF、Fe-MIL-100、Fe-MIL-53和Fe-MIL-101的FBP总释放率分别为72.9%、75.2%、78.3%和90.3%。
MOFs被证明是一种有前景的FBP药物递送选择，具有显著的负载百分比和相对较长的药物释放时间。
