Nelson D B, Peckham C S, Pearl K N, Chin K S, Garrett A J, Warren D E
Arch Dis Child. 1987 Apr;62(4):329-32. doi: 10.1136/adc.62.4.329.
One hundred and seventeen children and 41 teachers in day nurseries were screened for cytomegalovirus (CMV) viruria over a period of one year. Thirty two (27%) children and two (5%) teachers were found to be excreting virus on at least one occasion. Restriction endonuclease typing showed that virus strains isolated from the children were dissimilar, with the exception of those from sibling pairs and one unrelated pair. The virus isolate from one teacher matched those from two unrelated children, while the isolate from another teacher could not be distinguished from that from a sibling pair. The CMV serological state of the 41 teachers was not significantly different from 500 matched controls and no seroconversions occurred. It is concluded that although transmission of CMV among children and teachers may occur in day nurseries, the dissimilarity of most of the virus strains indicates that infection predominantly occurs outside. Furthermore, teachers in day nurseries showed no evidence of an increased risk of past CMV infection when compared with matched controls.
在一年的时间里，对日间托儿所的117名儿童和41名教师进行了巨细胞病毒（CMV）病毒尿筛查。发现32名（27%）儿童和2名（5%）教师至少有一次排出病毒。限制性内切酶分型显示，从儿童中分离出的病毒株各不相同，但来自同胞对和一对无亲属关系儿童的病毒株除外。一名教师的病毒分离株与两名无亲属关系儿童的病毒分离株匹配，而另一名教师的分离株与一对同胞的分离株无法区分。41名教师的CMV血清学状态与500名匹配对照无显著差异，且未发生血清转化。得出的结论是，虽然在日间托儿所儿童和教师之间可能发生CMV传播，但大多数病毒株的差异表明感染主要发生在托儿所之外。此外，与匹配对照相比，日间托儿所的教师没有显示出过去CMV感染风险增加的证据。
