Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland.
Department of Organic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.
Molecules. 2018 Oct 22;23(10):2724. doi: 10.3390/molecules23102724.
In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal disease models corresponding to human clinical situations. Beneficial features of the described isoxazole derivatives include low toxicity and good bioactivity at low doses. In a majority of studies, the activities of investigated compounds were comparable or even higher than registered reference drugs. Whenever possible, a plausible mechanism of action of the investigated compounds and their potential therapeutic utility were proposed. Among the described compounds, particular attention was paid to the class of immune stimulators with a potential application in chemotherapy patients.
在这篇综述中，我们报告了几类异恶唑衍生物的免疫调节特性，如免疫抑制、抗炎、免疫调节和免疫刺激化合物。这些化合物在各种模型中进行了测试，使用了来自啮齿动物和人类的常驻细胞、细胞系以及对应于人类临床情况的实验动物疾病模型。所描述的异恶唑衍生物的有益特征包括低毒性和低剂量下的良好生物活性。在大多数研究中，所研究化合物的活性与已注册的参考药物相当或更高。只要有可能，我们就提出了所研究化合物的作用机制及其潜在的治疗用途的合理假设。在所描述的化合物中，特别关注了一类具有在化疗患者中应用潜力的免疫刺激剂。
