小鼠肝炎病毒感染细胞中病毒蛋白的脂肪酸酰化。简报。
Fatty acid acylation of viral proteins in murine hepatitis virus-infected cells. Brief report.
作者信息
van Berlo M F, van den Brink W J, Horzinek M C, van der Zeijst B A
出版信息
Arch Virol. 1987;95(1-2):123-8. doi: 10.1007/BF01311339.
Abstract
The fatty acid acylation of the cell-associated virus-specific proteins of mouse hepatitis virus (A 59-strain) was studied. 3H-palmitate label was associated with E2, one of the two virion glycoproteins and its intracellular precursor gp 150. A 110 K protein, the unglycosylated apoprotein of gp 150, accumulated by tunicamycin treatment, also incorporated radiolabeled palmitic acid. The addition of fatty acid to the MHV-A 59 E 2 protein is therefore not dependent on glycosylation.
摘要
对小鼠肝炎病毒（A59株）细胞相关病毒特异性蛋白的脂肪酸酰化作用进行了研究。3H-棕榈酸标记与两种病毒粒子糖蛋白之一的E2及其细胞内前体gp150相关。经衣霉素处理积累的110K蛋白，即gp150的未糖基化载脂蛋白，也掺入了放射性标记的棕榈酸。因此，向MHV-A 59 E2蛋白添加脂肪酸不依赖于糖基化。
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