小鼠乳腺肿瘤病毒细胞受体的鉴定及其基因在16号染色体上的定位。
Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16.
作者信息
Hilkens J, van der Zeijst B, Buijs F, Kroezen V, Bleumink N, Hilgers J
出版信息
J Virol. 1983 Jan;45(1):140-7. doi: 10.1128/JVI.45.1.140-147.1983.
Abstract
Pseudotypes of vesicular stomatitis virus (VSV) containing envelope glycoproteins provided by C3H mammary tumor virus (MTV) instead of the normal VSV G-proteins were prepared and used to assay the presence of an MTV receptor on cells. The assay was specific as demonstrated by competition studies with excess MTV particles and neutralization of the pseudotypes with anti-MTV serum or monoclonal antibodies directed against MTV gp52. The MTV receptor was abundantly present on mouse cells but hardly detectable on nonmurine cells, including the Chinese hamster cell line E36. Somatic cell hybrids between E36 cells and GRS/A spontaneous leukemia cells (GRSL cells) and between E36 and GRS/A primary mammary tumor cells were made. The hybrids retained all Chinese hamster chromosomes but segregated mouse chromosomes. From the analysis of the isoenzymes and chromosomes of the hybrid cell lines we conclude that the gene for the receptor (MTVR-1) is located on mouse chromosome 16.
摘要
制备了含有C3H乳腺肿瘤病毒（MTV）提供的包膜糖蛋白而非正常水泡性口炎病毒（VSV）G蛋白的水泡性口炎病毒假型，并用于检测细胞上MTV受体的存在。竞争研究表明，该检测具有特异性，过量的MTV颗粒可与之竞争，抗MTV血清或针对MTV gp52的单克隆抗体可中和假型。MTV受体在小鼠细胞中大量存在，但在包括中国仓鼠细胞系E36在内的非小鼠细胞中几乎检测不到。构建了E36细胞与GRS/A自发白血病细胞（GRSL细胞）以及E36与GRS/A原发性乳腺肿瘤细胞之间的体细胞杂种。杂种保留了所有中国仓鼠染色体，但小鼠染色体发生了分离。通过对杂种细胞系的同工酶和染色体分析，我们得出结论，受体基因（MTVR-1）位于小鼠16号染色体上。
相似文献
1
Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16.小鼠乳腺肿瘤病毒细胞受体的鉴定及其基因在16号染色体上的定位。
J Virol. 1983 Jan;45(1):140-7. doi: 10.1128/JVI.45.1.140-147.1983.
2
Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5.嗜亲性小鼠白血病病毒受体在小鼠5号染色体上的定位。
J Exp Med. 1978 Aug 1;148(2):451-65. doi: 10.1084/jem.148.2.451.
3
Use of vesicular stomatitis virus pseudotypes to map viral receptor genes: Assignment of RD114 virus receptor gene to human chromosome 19.利用水疱性口炎病毒假型来定位病毒受体基因：将RD114病毒受体基因定位于人类第19号染色体。
J Virol. 1980 Aug;35(2):575-80. doi: 10.1128/JVI.35.2.575-580.1980.
4
Identification of a mouse gene required for binding of Rauscher MuLV envelope gp70.
Somatic Cell Genet. 1979 Jan;5(1):39-49. doi: 10.1007/BF01538785.
5
Human T cell leukemia viruses use a receptor determined by human chromosome 17.人类T细胞白血病病毒使用一种由人类17号染色体决定的受体。
Science. 1988 Dec 16;242(4885):1557-9. doi: 10.1126/science.3201246.
6
A novel membrane protein is a mouse mammary tumor virus receptor.一种新型膜蛋白是小鼠乳腺肿瘤病毒受体。
J Virol. 1998 Apr;72(4):3066-71. doi: 10.1128/JVI.72.4.3066-3071.1998.
7
Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus.小鼠转铁蛋白受体1是小鼠乳腺肿瘤病毒的细胞进入受体。
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12386-90. doi: 10.1073/pnas.192360099. Epub 2002 Sep 6.
8
Localization of the receptor gene for type D simian retroviruses on human chromosome 19.D型猿猴逆转录病毒受体基因在人类19号染色体上的定位。
J Virol. 1990 Dec;64(12):6214-20. doi: 10.1128/JVI.64.12.6214-6220.1990.
9
Mice with spontaneous mammary tumors develop type-specific neutralizing and cytotoxic antibodies against the mouse mammary tumor virus envelope protein gp52.患有自发性乳腺肿瘤的小鼠会产生针对小鼠乳腺肿瘤病毒包膜蛋白gp52的类型特异性中和抗体和细胞毒性抗体。
J Virol. 1979 Oct;32(1):131-9. doi: 10.1128/JVI.32.1.131-139.1979.
10
Normal X chromosome induced reversion in the direction of chromosome segregation in mouse-Chinese hamster somatic cell hybrids.正常X染色体诱导小鼠-中国仓鼠体细胞杂种中染色体分离方向的回复。
Exp Cell Res. 1983 Oct;148(1):265-72. doi: 10.1016/0014-4827(83)90207-0.
引用本文的文献
1
Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus.小鼠转铁蛋白受体1是小鼠乳腺肿瘤病毒的细胞进入受体。
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12386-90. doi: 10.1073/pnas.192360099. Epub 2002 Sep 6.
2
Preferential binding of mouse mammary tumor virus to B lymphocytes.小鼠乳腺肿瘤病毒与B淋巴细胞的优先结合。
J Virol. 1999 Sep;73(9):7899-902. doi: 10.1128/JVI.73.9.7899-7902.1999.
3
A novel membrane protein is a mouse mammary tumor virus receptor.一种新型膜蛋白是小鼠乳腺肿瘤病毒受体。
J Virol. 1998 Apr;72(4):3066-71. doi: 10.1128/JVI.72.4.3066-3071.1998.
4
Development of retroviral vectors as safe, targeted gene delivery systems.逆转录病毒载体作为安全、靶向性基因递送系统的开发。
J Mol Med (Berl). 1996 Apr;74(4):171-82. doi: 10.1007/BF00204747.
5
The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.人类免疫缺陷病毒1型（HIV-1）的CD4受体及其在促进HIV-1感染中的核心作用。
Microbiol Rev. 1995 Mar;59(1):63-93. doi: 10.1128/mr.59.1.63-93.1995.
6
Localization of the gene for the vitamin B12 binding protein, transcobalamin II, near the centromere on mouse chromosome 11, linked with the hemoglobin alpha-chain locus.维生素B12结合蛋白转钴胺素II基因在小鼠11号染色体着丝粒附近的定位，与血红蛋白α链基因座连锁。
Biochem Genet. 1985 Feb;23(1-2):139-53. doi: 10.1007/BF00499119.
7
Fatty acid acylation of viral proteins in murine hepatitis virus-infected cells. Brief report.小鼠肝炎病毒感染细胞中病毒蛋白的脂肪酸酰化。简报。
Arch Virol. 1987;95(1-2):123-8. doi: 10.1007/BF01311339.
8
Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat.从肾腺癌细胞系中分离出的外源性小鼠乳腺肿瘤病毒前病毒DNA在长末端重复序列的U3区域存在改变。
J Virol. 1986 Oct;60(1):1-11. doi: 10.1128/JVI.60.1.1-11.1986.
9
A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression.位于11号染色体上的一个含小鼠同源异型盒基因：序列及组织特异性表达
Nucleic Acids Res. 1987 Sep 11;15(17):6773-86. doi: 10.1093/nar/15.17.6773.
10
AvaII RFLP at the human apolipoprotein CII (APO CII) gene locus.人载脂蛋白CII（APO CII）基因座的AvaII限制性片段长度多态性
Nucleic Acids Res. 1987 Aug 25;15(16):6769. doi: 10.1093/nar/15.16.6769.
本文引用的文献
1
CYTOPATHIC EFFECT OF RUBELLA VIRUS IN A RABBIT-CORNEA CELL LINE.风疹病毒在兔角膜细胞系中的细胞病变效应
Science. 1965 Aug 6;149(3684):633-4. doi: 10.1126/science.149.3684.633.
2
SYRIAN HAMSTER FIBROBLAST CELL LINE BHK21 AND ITS DERIVATIVES.叙利亚仓鼠成纤维细胞系BHK21及其衍生物
Nature. 1964 Sep 26;203:1355-7. doi: 10.1038/2031355a0.
3
Viral epitopes and monoclonal antibodies: isolation of blocking antibodies that inhibit virus neutralization.
Science. 1981 Jul 24;213(4506):447-9. doi: 10.1126/science.6264601.
4
Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction.
J Supramol Struct. 1980;14(3):343-52. doi: 10.1002/jss.400140308.
5
Common surface receptors on both mouse and rat cells distinguish different classes of mouse mammary tumor viruses.
Virology. 1981 Mar;109(2):257-66. doi: 10.1016/0042-6822(81)90497-9.
6
Monoclonal and polyclonal antibody studies of VSV(hrMMTV) pseudotypes.水泡性口炎病毒（hrMMTV）假型的单克隆抗体和多克隆抗体研究。
Virology. 1982 Jul 15;120(1):54-64. doi: 10.1016/0042-6822(82)90006-x.
7
Topographical analysis of viral epitopes using monoclonal antibodies: mechanism of virus neutralization.利用单克隆抗体对病毒表位进行拓扑分析：病毒中和机制
Virology. 1981 Nov;115(1):20-32. doi: 10.1016/0042-6822(81)90085-4.
8
C3H/HeN mammary tumor-bearing mice develop type-specific neutralizing antibodies and group-specific precipitating antibodies for the mouse mammary tumor virus.携带C3H/HeN乳腺肿瘤的小鼠会产生针对小鼠乳腺肿瘤病毒的型特异性中和抗体和组特异性沉淀抗体。
J Virol. 1980 Jan;33(1):123-8. doi: 10.1128/JVI.33.1.123-128.1980.
9
A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.小鼠及体细胞杂种在淀粉凝胶中的酶多态性、连锁关系及电泳条件综述。
J Histochem Cytochem. 1973 Dec;21(12):1066-81. doi: 10.1177/21.12.1066.
10
A new electrophoretic technique for mouse, human, and Chinese hamster galactokinase.一种用于小鼠、人类和中国仓鼠半乳糖激酶的新型电泳技术。
Cytogenet Cell Genet. 1974;13(3):275-8. doi: 10.1159/000130279.
Zotero 插件