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接受哌醋甲酯治疗的 ADHD 患者，人类内源性逆转录病毒-H 活性下降与 ADHD 症状改善呈平行关系。

The Decrease in Human Endogenous Retrovirus-H Activity Runs in Parallel with Improvement in ADHD Symptoms in Patients Undergoing Methylphenidate Therapy.

机构信息

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Child Neurology and Psychiatry Unit, Systems Medicine Department, University Hospital Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

出版信息

Int J Mol Sci. 2018 Oct 23;19(11):3286. doi: 10.3390/ijms19113286.

DOI:10.3390/ijms19113286
PMID:30360480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6274708/
Abstract

Increasing scientific evidence demonstrated the deregulation of human endogenous retroviruses (HERVs) expression in complex diseases, such as cancer, autoimmune, psychiatric, and neurological disorders. The dynamic regulation of HERV activity and their responsiveness to a variety of environmental stimuli designate HERVs as genetic elements that could be modulated by drugs. Methylphenidate (MPH) is widely used in the treatment of attention deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the time course of human endogenous retrovirus H (HERV-H) expression in peripheral blood mononuclear cells (PBMCs) with respect to clinical response in ADHD patients undergoing MPH therapy. A fast reduction in HERV-H activity in ADHD patients undergoing MPH therapy was observed in parallel with an improvement in clinical symptoms. Moreover, when PBMCs from drug-naïve patients were cultured in vitro, HERV-H expression increased, while no changes in the expression levels were found in ADHD patients undergoing therapy. This suggests that MPH could affect the HERV-H activity and supports the hypothesis that high expression levels of HERV-H could be considered a distinctive trait of ADHD patients.

摘要

越来越多的科学证据表明，人类内源性逆转录病毒（HERV）的表达在复杂疾病中失调，如癌症、自身免疫、精神和神经紊乱。HERV 活性的动态调节及其对各种环境刺激的反应性将 HERV 标记为可被药物调节的遗传元件。哌醋甲酯（MPH）广泛用于治疗注意力缺陷多动障碍（ADHD）。本研究旨在评估 ADHD 患者接受 MPH 治疗时外周血单个核细胞（PBMC）中人类内源性逆转录病毒 H（HERV-H）表达的时间过程与临床反应的关系。在接受 MPH 治疗的 ADHD 患者中，HERV-H 活性迅速降低，同时临床症状改善。此外，当来自未经药物治疗的患者的 PBMC 在体外培养时，HERV-H 表达增加，而接受治疗的 ADHD 患者的表达水平没有变化。这表明 MPH 可能会影响 HERV-H 活性，并支持 HERV-H 高表达水平可被视为 ADHD 患者的独特特征的假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/93379b62c2e2/ijms-19-03286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/03ce261f5e38/ijms-19-03286-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/cbbaa139f526/ijms-19-03286-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/93379b62c2e2/ijms-19-03286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/03ce261f5e38/ijms-19-03286-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/cbbaa139f526/ijms-19-03286-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed9/6274708/93379b62c2e2/ijms-19-03286-g003.jpg

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