神经系统疾病中的内源性逆转录病毒
Endogenous Retroviruses in Nervous System Disorders.
作者信息
Gröger Victoria, Emmer Alexander, Staege Martin S, Cynis Holger
机构信息
Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, 06120 Halle (Saale), Germany.
Department of Neurology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
出版信息
Pharmaceuticals (Basel). 2021 Jan 16;14(1):70. doi: 10.3390/ph14010070.
Abstract
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.
摘要
人类内源性逆转录病毒（HERV）已被认为与包括多发性硬化症和肌萎缩侧索硬化症在内的几种神经系统疾病的发病机制有关。HERV衍生的RNA和蛋白质对神经元细胞的毒性已得到证实。HERV参与目前无法治愈疾病的发病机制，这可能为基于小分子或治疗性抗体抑制HERV活性的新治疗策略提供依据。
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