Department of Cardiology, Aalborg University Hospital, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark.
Nutrients. 2018 Oct 23;10(11):1570. doi: 10.3390/nu10111570.
Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemic stroke and its subtypes. A case-cohort study was conducted based on the Danish cohort study Diet, Cancer, and Health, which includes 57,053 subjects aged 50⁻64 years at enrolment. A subcohort ( = 3500) was randomly drawn from the whole cohort. All ischemic stroke cases were validated and categorized into subtypes. The lipophilic index was calculated based on fatty acid profiles in adipose tissue. Subjects were divided into quintiles and a weighted Cox proportional hazards regression model was used to calculate hazard ratios. After appropriate exclusions, a subcohort of 3194 subjects and 1752 cases of ischemic stroke were included. When comparing the fifth quintile of the lipophilic index with the first quintile, the hazard ratio for ischemic stroke was 0.92 (95% confidence interval 0.75, 1.13) and the trend across quintiles was not statistically significant ( = 0.1727). In conclusion, no association was found between the lipophilic index and ischemic stroke or its subtypes.
饮食可能通过多种机制影响缺血性中风的风险。一个潜在的、迄今为止未知的机制可能与亲脂指数有关，亲脂指数是一种新的、方便的膜流动性指标。本研究调查了脂肪组织亲脂指数与缺血性中风及其亚型之间的关系。这项病例-队列研究基于丹麦的 Diet，Cancer，and Health 队列研究，该研究纳入了 57053 名年龄在 50⁻64 岁的受试者。从整个队列中随机抽取一个亚队列（=3500）。所有缺血性中风病例均经过验证，并分为亚型。亲脂指数是根据脂肪组织中的脂肪酸谱计算得出的。受试者被分为五组，并使用加权 Cox 比例风险回归模型计算风险比。经过适当排除后，纳入了 3194 名受试者和 1752 例缺血性中风病例。当将亲脂指数的第五个五分位数与第一个五分位数进行比较时，缺血性中风的风险比为 0.92（95%置信区间 0.75，1.13），五分位数之间的趋势没有统计学意义（=0.1727）。总之，亲脂指数与缺血性中风或其亚型之间没有关联。
