Department of Anatomy, Faculty of Medicine, 18th Floor, Pre-Clinical Block, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif 56000, Kuala Lumpur, Malaysia.
Mini Rev Med Chem. 2019;19(5):381-394. doi: 10.2174/1389557518666181025155204.
The incidence of diabetes mellitus (DM) is on the rise, worldwide. One of the main complications in DM is delayed wound healing and it often requires amputation. Various drugs were used to treat DM but they presented with adverse effects. Often, patients failed to comply with such treatment. This opened the door for complementary and alternative medicine. In the present review, we explored the molecular concept of wound healing occurring in different stages with special emphasis to DM. We also highlighted the potential herbal products such as NF3 (Chinese 2-Herb Formula), Zicao, Jing Wan Hong ointment, Aleo vera, mixture of Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna, Phenol-rich compound sweet gel, Jinchuang ointment, San-huang-sheng-fu (S) oil, Yi Bu A Jie extract, Astragali Radix (AR) and Rehmanniae Radix (RR), Yiqi Huayu, Tangzu yuyang ointment, Shengji Huayu recipe, Angelica sinensis, Lithospermun erythrorhison, Hippophae rhamnoides L., Curcuma longa and Momordica charantia that could be used effectively to treat DM wounds. Future clinical trials are needed for designing potential drugs which may be effective in treating DM wounds.
糖尿病（DM）的发病率在全球范围内呈上升趋势。DM 的主要并发症之一是伤口愈合延迟，这通常需要截肢。各种药物被用于治疗 DM，但它们都有不良反应。患者常常无法遵守这种治疗。这为补充和替代医学打开了大门。在本综述中，我们探讨了不同阶段发生的伤口愈合的分子概念，特别强调了 DM。我们还强调了一些有潜力的草药产品，如 NF3（中药 2 味配方）、紫草、京万红软膏、芦荟、凤尾蕨、没药、芦荟和指甲花、富酚化合物甜凝胶、金疮软膏、三黄生福（S）油、益补阿杰提取物、黄芪（AR）和地黄（RR）、益气化瘀、糖组玉阳软膏、圣基化瘀配方、当归、丹参、沙棘、大黄和苦瓜，这些产品可有效治疗 DM 伤口。需要进行未来的临床试验，以设计可能对治疗 DM 伤口有效的潜在药物。
