Nakamura Michihiro
Department of Organ Anatomy & Nanomedicine, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Enzymes. 2018;44:137-173. doi: 10.1016/bs.enz.2018.08.002. Epub 2018 Oct 5.
Medical imaging technology using nanoparticles has several advantages from it varies functional properties. As we described previous chapters, mesoporous silica nanoparticles demonstrated great contribution for nanomedicine progress and it has been expected to cause an innovation in medical field. Recently we developed a novel type of silica nanoparticles, organosilica nanoparticles. Organosilica nanoparticles are both structurally and functionally different from common silica nanoparticles by including mesoporous silica nanoparticles. The organosilica nanoparticles are inherent organic-inorganic hybrid nanomaterials. The interior and exterior functionalities of organosilica nanoparticles are effective for their internal and surface functionalization. Medical imaging using organosilica nanoparticles is making a new field of nano-medical imaging. Multifunctionalizations peculiar to organosilica nanoparticles enable to construct novel medical imaging system. In this chapter we will introduce organosilica nanoparticles, and its applications on advanced medical imaging.
利用纳米粒子的医学成像技术因其多样的功能特性而具有诸多优势。正如我们在前几章中所描述的，介孔二氧化硅纳米粒子对纳米医学的发展做出了巨大贡献，并且有望在医学领域引发一场革新。最近，我们开发了一种新型的二氧化硅纳米粒子——有机硅纳米粒子。有机硅纳米粒子在结构和功能上与包括介孔二氧化硅纳米粒子在内的普通二氧化硅纳米粒子均有所不同。有机硅纳米粒子是固有的有机-无机杂化纳米材料。有机硅纳米粒子的内部和外部功能对其内部和表面功能化十分有效。使用有机硅纳米粒子的医学成像正在开创一个纳米医学成像的新领域。有机硅纳米粒子特有的多功能化能够构建新型医学成像系统。在本章中，我们将介绍有机硅纳米粒子及其在先进医学成像中的应用。
