CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
Pharmacol Res. 2020 May;155:104742. doi: 10.1016/j.phrs.2020.104742. Epub 2020 Mar 6.
The application of nanomaterials is regarded nowadays as a highly promising approach for overcoming the limitations of the currently available cancer treatments, contributing for the creation of more effective, precise, and safer therapies. In the last years, organosilica nanoparticles arisen as alternatives to the most common mesoporous silica nanoparticles. The organosilica nanoparticles combine the advantages of the mesoporous silica, such as structural stability and mesoporous structure, with the increased biocompatibility and biodegradability of organic materials. Therefore, the variety of organic bridges that can be incorporated into the silica matrix allowed the development of new and exciting compositions, properties, and functions for improving the therapeutic effectiveness of the anticancer nanomedicines. In this review, the strategies that have been explored to create stimuli-responsive organosilica-based drug delivery systems are highlighted, describing the practical approaches and mechanisms controlling the drug release. Additionally, the organosilica nanoparticles surface modifications aimed for increasing the blood circulation time and the tumor targeting are also described.
如今，纳米材料的应用被视为克服当前癌症治疗方法局限性的一种极具前景的方法，有助于创造更有效、更精确和更安全的疗法。近年来，有机硅纳米颗粒作为最常见的介孔硅纳米颗粒的替代品出现。有机硅纳米颗粒结合了介孔硅的优点，如结构稳定性和介孔结构，以及有机材料的生物相容性和可降解性的提高。因此，可以将各种有机桥接到硅基质中，从而开发出具有新颖和令人兴奋的组成、性质和功能的纳米药物，以提高抗癌纳米药物的治疗效果。在这篇综述中，突出强调了为创建对刺激有响应的基于有机硅的药物输送系统而探索的策略，描述了控制药物释放的实际方法和机制。此外，还描述了旨在增加血液循环时间和肿瘤靶向的有机硅纳米颗粒表面改性。
