Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
J Am Coll Cardiol. 2018 Oct 30;72(18):2198-2212. doi: 10.1016/j.jacc.2018.08.2150.
It has long been recognized that the bone marrow is the primary site of origin for circulating monocytes that may later become macrophages in atherosclerotic lesions. However, only in recent times has the complex relationship among the bone marrow, monocytes/macrophages, and atherosclerotic plaques begun to be understood. Moreover, the systemic nature of these interactions, which also involves additional compartments such as extramedullary hematopoietic sites (i.e., spleen), is only just becoming apparent. In parallel, progressive advances in imaging and cell labeling techniques have opened new opportunities for in vivo imaging of monocyte/macrophage trafficking in atherosclerotic lesions and at the systemic level. In this Part 3 of a 4-part review series covering the macrophage in cardiovascular disease, the authors intersect systemic biology with advanced imaging techniques to explore monocyte and macrophage dynamics in the cardiovascular system, with an emphasis on how events at the systemic level might affect local atherosclerotic plaque biology.
长期以来，人们一直认为骨髓是循环单核细胞的主要起源地，这些单核细胞后来可能成为动脉粥样硬化病变中的巨噬细胞。然而，直到最近，骨髓、单核细胞/巨噬细胞和动脉粥样硬化斑块之间的复杂关系才开始被理解。此外，这些相互作用的系统性，还涉及其他部位，如骨髓外造血部位（即脾脏），这一点才刚刚显现出来。与此同时，成像和细胞标记技术的不断进步为在动脉粥样硬化病变和全身水平上对单核细胞/巨噬细胞迁移进行体内成像开辟了新的机会。在涵盖心血管疾病中巨噬细胞的四部分综述系列的第 3 部分中，作者将系统生物学与先进的成像技术相结合，探讨了心血管系统中单核细胞和巨噬细胞的动态，重点关注全身水平的事件如何影响局部动脉粥样硬化斑块的生物学。
