Abrams Stephen L, Follo Matilde Y, Steelman Linda S, Lertpiriyapong Kvin, Cocco Lucio, Ratti Stefano, Martelli Alberto M, Candido Saverio, Libra Massimo, Murata Ramiro M, Rosalen Pedro L, Montalto Giuseppe, Cervello Melchiorre, Gizak Agnieszka, Rakus Dariusz, Mao Weifeng, Lombardi Paolo, McCubrey James A
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA.
Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Adv Biol Regul. 2019 Jan;71:172-182. doi: 10.1016/j.jbior.2018.10.003. Epub 2018 Oct 17.
Berberine (BBR) is a common nutraceutical consumed by millions worldwide. BBR has many different effects on human health, e.g., diabetes, diarrhea, inflammation and now more recently it has been proposed to have potent anti-cancer effects. BBR has been shown to suppress the growth of cancer cells more than normal cells. BBR has been proposed to exert its growth-inhibitory effects by many different biochemical mechanisms including: suppression of cell cycle progression, induction of reactive oxygen species, induction of apoptosis and autophagy and interactions with DNA potentially leading to DNA damage, and altered gene expression. Pancreatic cancer is a leading cancer worldwide associated with a poor prognosis. As our population ages, pancreatic cancer has an increasing incidence and will likely become the second leading cause of death from cancer. There are few truly-effective therapeutic options for pancreatic cancer. Surgery and certain chemotherapeutic drugs are used to treat pancreatic cancer patients. Novel approaches to treat pancreatic cancer patients are direly needed as they usually survive for less than a year after being diagnosed. In the following manuscript, we discuss the abilities of BBR and certain chemically-modified BBRs (NAX compounds) to suppress growth of pancreatic cancer cells.
黄连素（BBR）是一种全球数百万人食用的常见营养保健品。BBR对人体健康有许多不同的影响，例如糖尿病、腹泻、炎症，最近有人提出它具有强大的抗癌作用。已证明BBR对癌细胞生长的抑制作用大于正常细胞。有人提出BBR通过多种不同的生化机制发挥其生长抑制作用，包括：抑制细胞周期进程、诱导活性氧生成、诱导细胞凋亡和自噬以及与DNA相互作用可能导致DNA损伤和基因表达改变。胰腺癌是全球主要的癌症之一，预后较差。随着人口老龄化，胰腺癌的发病率不断上升，很可能成为癌症死亡的第二大主要原因。胰腺癌几乎没有真正有效的治疗选择。手术和某些化疗药物用于治疗胰腺癌患者。由于胰腺癌患者通常在确诊后存活时间不到一年，因此迫切需要治疗胰腺癌患者的新方法。在以下手稿中，我们讨论了BBR和某些化学修饰的BBR（NAX化合物）抑制胰腺癌细胞生长的能力。
