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天然产物在农业中的影响和前景：探索植物和微生物中次生代谢产物多样性的新技术，应用于农业。

The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture.

机构信息

Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, USA.

Department of Molecular, Cell, and Developmental Biology, Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

EMBO Rep. 2018 Nov;19(11). doi: 10.15252/embr.201846824. Epub 2018 Oct 25.

DOI:10.15252/embr.201846824
PMID:30361392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6216283/
Abstract

Natural products from plants and microorganisms are potent bioactive molecules that have been used in medicine, agriculture and cosmetics. Genomics and synthetic biology offer new tools to further explore their diversity for applications as fungicides or herbicides. [Image: see text]

摘要

植物和微生物来源的天然产物是有效的生物活性分子，已被应用于医药、农业和化妆品领域。基因组学和合成生物学为进一步探索其多样性，将其作为杀菌剂或除草剂应用提供了新工具。[图片：见正文]

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本文引用的文献

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Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.基于抗性基因的导向发现具有全新作用模式的天然产物型除草剂。
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Nat Rev Microbiol. 2015 Aug;13(8):509-23. doi: 10.1038/nrmicro3496. Epub 2015 Jun 29.
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Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.抗生素。利用新型灰黄霉素靶向 DNA 酶 N 治疗结核病。
Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690.
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De novo production of the plant-derived alkaloid strictosidine in yeast.酵母中植物源生物碱士的宁苷的从头合成。
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High-level semi-synthetic production of the potent antimalarial artemisinin.高效半合成制备强效抗疟药物青蒿素。
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