Suzuki M, Ito A, Mori Y, Hayashi Y, Matsuta K
Biochem Med Metab Biol. 1987 Apr;37(2):177-83. doi: 10.1016/0885-4505(87)90024-7.
The levels of kallikrein and collagenase in synovial fluid from rheumatoid arthritis (RA) patients were examined and the role of kallikrein in procollagenase activation is discussed. Both prekallikrein and active kallikrein in synovial fluid from patients with RA were significantly elevated when compared to synovial fluid from patients with osteoarthritis (OA). In RA synovial fluid, the ratio of the active form to total kallikrein was also higher than that in OA synovial fluid. Both active collagenase and the alpha 2-macroglobulin (alpha 2M)-collagenase complex in RA synovial fluid were higher than in OA synovial fluid. A partial correlation (r = 0.58) between active kallikrein and total collagenase (active and alpha 2M-collagenase complex) was observed in RA synovial fluid. These observations indicate that both kallikrein and collagenase are associated with the destruction of cartilage, but the role of kallikrein in procollagenase activation was not fully clarified.
检测了类风湿性关节炎（RA）患者滑液中激肽释放酶和胶原酶的水平，并讨论了激肽释放酶在原胶原酶激活中的作用。与骨关节炎（OA）患者的滑液相比，RA患者滑液中的前激肽释放酶和活性激肽释放酶均显著升高。在RA滑液中，活性形式与总激肽释放酶的比率也高于OA滑液。RA滑液中的活性胶原酶和α2-巨球蛋白（α2M）-胶原酶复合物均高于OA滑液。在RA滑液中观察到活性激肽释放酶与总胶原酶（活性和α2M-胶原酶复合物）之间存在部分相关性（r = 0.58）。这些观察结果表明，激肽释放酶和胶原酶均与软骨破坏有关，但激肽释放酶在原胶原酶激活中的作用尚未完全阐明。
