甲氨蝶呤减少银屑病中白三烯B4诱导的多形核白细胞表皮内聚集

Reduction of leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes by methotrexate in psoriasis.

作者信息

Lammers A M, van de Kerkhof P C, Mier P D

出版信息

Br J Dermatol. 1987 May;116(5):667-71. doi: 10.1111/j.1365-2133.1987.tb05900.x.

DOI:10.1111/j.1365-2133.1987.tb05900.x

Abstract

The leukotriene B4 (LTB4)-induced intraepidermal accumulation of polymorphonuclear leukocytes (PMN) was quantified, using an elastase assay, in psoriatic patients receiving methotrexate and in untreated psoriatic patients. Methotrexate in therapeutic dosages inhibited PMN infiltration in six patients who had improved considerably on treatment with the drug, a gradual increase being seen during the days on which no methotrexate was taken. Two patients were in relapse, despite methotrexate treatment, and both failed to show any change in LTB4-induced accumulation of PMN.

摘要

采用弹性蛋白酶测定法，对接受甲氨蝶呤治疗的银屑病患者和未经治疗的银屑病患者中白三烯B4（LTB4）诱导的多形核白细胞（PMN）表皮内积聚情况进行了定量分析。治疗剂量的甲氨蝶呤抑制了6例在药物治疗后病情显著改善患者的PMN浸润，在未服用甲氨蝶呤的日子里，PMN浸润呈逐渐增加趋势。尽管接受了甲氨蝶呤治疗，但仍有2例患者病情复发，且这2例患者在LTB4诱导的PMN积聚方面均未显示出任何变化。