Yanishi Masaaki, Kinoshita Hidefumi, Tsukaguchi Hiroyasu, Kimura Yutaka, Koito Yuya, Sugi Motohiko, Matsuda Tadashi
Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.
Department of Urology and Andrology, Graduate School of Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Int Urol Nephrol. 2019 Jan;51(1):79-83. doi: 10.1007/s11255-018-2015-6. Epub 2018 Oct 25.
Measuring muscle mass is an important step in detecting sarcopenia. The evaluation of sarcopenia is also important for kidney transplant recipients. Methods for estimating muscle mass have been established using computed tomography or magnetic resonance imaging, which are considered the gold standards. But these methods are invasive and costly, and there is a need for a more practical and simple method using blood samples from kidney transplant recipients.
The study population was 62 patients who underwent kidney transplantation at Kansai Medical University Hospital, and were evaluated from August to October 2017. Muscle mass was measured using dual-energy X-ray absorptiometry. Serum creatinine and cystatin C levels were measured by immunoassay.
We analyzed 62 transplant recipients who met the inclusion criteria (20 females and 42 males, mean age of 45.6 ± 12.7 years). The creatinine/cystatin C ratio in the male group was > 1, whereas the creatinine/cystatin C ratio in the female group was < 1. Muscle mass was significantly larger in the male group than the female group. There was a significant positive correlation between the skeletal muscle index and creatinine/cystatin C ratio in the male (r = 0.553; p < 0.001) and female groups (r = 0.675; p < 0.001).
The creatinine/cystatin C ratio is appropriate for evaluating muscle mass in kidney transplant recipients.
测量肌肉量是检测肌肉减少症的重要步骤。对肾移植受者而言，评估肌肉减少症也很重要。已使用计算机断层扫描或磁共振成像建立了估计肌肉量的方法，这些方法被视为金标准。但这些方法具有侵入性且成本高昂，因此需要一种更实用、更简单且基于肾移植受者血样的方法。
研究对象为62例在关西医科大学医院接受肾移植的患者，于2017年8月至10月进行评估。使用双能X线吸收法测量肌肉量。通过免疫测定法测量血清肌酐和胱抑素C水平。
我们分析了62例符合纳入标准的移植受者（20例女性和42例男性，平均年龄45.6±12.7岁）。男性组的肌酐/胱抑素C比值>1，而女性组的肌酐/胱抑素C比值<1。男性组的肌肉量显著大于女性组。男性组（r = 0.553；p < 0.001）和女性组（r = 0.675；p < 0.001）的骨骼肌指数与肌酐/胱抑素C比值之间存在显著正相关关系。
肌酐/胱抑素C比值适用于评估肾移植受者的肌肉量。
