Yanishi Masaaki, Tsukaguchi Hiroyasu, Kimura Yutaka, Koito Yuya, Yoshida Kenji, Seo Maiko, Jino Eri, Sugi Motohiko, Kinoshita Hidefumi, Matsuda Tadashi
Department of Urology and Andrology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
2nd Department of Internal Medicine, Division of Nephrology, Kansai Medical University, Osaka, Japan.
Int Urol Nephrol. 2017 Oct;49(10):1779-1784. doi: 10.1007/s11255-017-1661-4. Epub 2017 Jul 19.
Sarcopenia is an involuntary decline in skeletal muscle mass, strength, and function that normally proceed with aging but may develop faster under some chronic disease conditions. In this study, we compared the physical activity between sarcopenia and non-sarcopenia subgroups in kidney transplant recipients.
Fifty-eight recipients (42 males and 16 females) were enrolled in this study. Mean age of the recipients was 46.6 ± 12.7 years. Mean duration of dialysis was 2.8 ± 4.0 years. Diagnostic criteria for sarcopenia referred to those of the Asia Working Group for Sarcopenia. The physical activity was assessed using the International Physical Activity Questionnaire, and the intensity of physical activity was expressed in metabolic equivalents (MET).
Based on the skeletal muscle mass index (SMI) as well as functional index (HGS, walking speed), the participants were classified into the three subgroups: 12 patients (20.7%) with sarcopenia (Group 1), 25 (43.1%) with presarcopenia (Group 2), and 21 (36.2%) non-sarcopenia (Group 3). Analysis with ANOVA and pairwise comparisons showed that physical activity measured as total MET-min/week was significantly greater in Group 2 (1292 ± 633) than in Group (1484 ± 262). Moreover, physical activity of Group 3 (2461 ± 1339)-min/week was significantly greater than those of Groups 1 and 2.
Our data indicate that physical activity is restricted under presarcopenia and sarcopenia after kidney transplantation. Considering that the recipient age is now increasing, proper management of sarcopenia may become more crucial to improve the kidney survival and lifetime prognosis of the kidney transplant recipients.
肌肉减少症是骨骼肌质量、力量和功能的非自愿性下降，通常随年龄增长而发生，但在某些慢性疾病情况下可能发展得更快。在本研究中，我们比较了肾移植受者中肌肉减少症亚组和非肌肉减少症亚组之间的身体活动情况。
本研究纳入了58名受者（42名男性和16名女性）。受者的平均年龄为46.6±12.7岁。平均透析时间为2.8±4.0年。肌肉减少症的诊断标准参照亚洲肌肉减少症工作组的标准。使用国际体力活动问卷评估身体活动情况，身体活动强度以代谢当量（MET）表示。
根据骨骼肌质量指数（SMI）以及功能指数（握力、步行速度），将参与者分为三个亚组：12名（20.7%）患有肌肉减少症的患者（第1组），25名（43.1%）患有肌肉减少症前期的患者（第2组），以及21名（36.2%）非肌肉减少症患者（第3组）。方差分析和两两比较分析显示，以每周总MET-分钟数衡量的身体活动在第2组（1292±633）显著高于第1组（1484±262）。此外，第3组（2461±1339）每周的身体活动显著高于第1组和第2组。
我们的数据表明，肾移植后肌肉减少症前期和肌肉减少症状态下身体活动受到限制。考虑到目前受者年龄在增加，适当管理肌肉减少症对于改善肾移植受者的肾脏存活率和生存期预后可能变得更加关键。
