Lai Joshua, Heran Manraj K S, Stoessl A Jon, Gooderham Peter A
Department of Neurology University of British Columbia Vancouver British Columbia Canada.
Department of Radiology University of British Columbia Vancouver British Columbia Canada.
Mov Disord Clin Pract. 2017 Mar 27;4(4):607-611. doi: 10.1002/mdc3.12480. eCollection 2017 Jul-Aug.
Dural arteriovenous fistula (dAVF) rarely presents with a syndrome of reversible parkinsonism and rapidly progressive dementia, which has been described in 19 patients to date. However, its presenting features, pathophysiology, and response to treatment have not been reviewed.
We report the clinical course and treatment of two novel patients with this syndrome.
Despite severe presentations, both patients recovered fully after fistula obliteration.
Atypical parkinsonism with early cognitive changes and other focal neurological signs, along with features such as pulsatile tinnitus or worsening headache, should raise the possibility of dAVF. When treated, this syndrome is nearly always reversible, highlighting the importance of early diagnosis.
硬脑膜动静脉瘘（dAVF）很少表现为可逆性帕金森综合征和快速进展性痴呆综合征，迄今为止已有19例患者被描述。然而，其临床表现、病理生理学及治疗反应尚未得到综述。
我们报告了两名患有该综合征的新病例的临床过程及治疗情况。
尽管症状严重，但两名患者在瘘管闭塞后均完全康复。
伴有早期认知改变和其他局灶性神经体征的非典型帕金森综合征，以及搏动性耳鸣或头痛加重等特征，应提高dAVF的可能性。经治疗后，该综合征几乎总是可逆的，这凸显了早期诊断的重要性。
