Jankovic Joseph
Parkinson's Disease Center and Movement Disorders Clinic Department of Neurology Baylor College of Medicine Houston Texas USA.
Mov Disord Clin Pract. 2016 Jan 29;3(2):216-217. doi: 10.1002/mdc3.12329. eCollection 2016 Mar-Apr.
Although rest tremor is the typical form of tremor associated with Parkinson's disease (PD), particularly the tremor-dominant subtype,1 parkinsonian patients may also exhibit postural tremor. In many parkinsonian patients, this postural tremor emerges after a latency of a few seconds or even minutes. In our original description, we coined the term "re-emergent tremor" to differentiate this postural tremor from essential tremor, which occurs without any latency, and to link it to PD rest tremor that is "reset" after some latency when a new holding posture is assumed.2 The relationship of this re-emergent tremor to the typical rest tremor is supported by the observation that this tremor shares many characteristics with the typical rest tremor, such as the same, 3 to 5-Hz frequency, occasional supinating-pronating component, and relatively good response to dopaminergic therapy. Rarely, postural tremor, occurring after a brief (2-4 seconds) latency can be seen even without observable rest tremor.3 In most patients with PD, it is the postural (re-emergent) tremor that is more troublesome for them than the typical rest tremor, because this re-emergent tremor interferes with their ability to hold objects, such as newspapers, against gravity and results in spilling of liquids. Postural tremor of PD is often misdiagnosed as essential tremor, and this diagnostic challenge can be further confounded when both conditions coexist.4 When that occurs, the postural tremor is present without latency, although the amplitude may gradually increase as the underlying re-emergent tremor becomes more evident.
尽管静止性震颤是与帕金森病(PD)相关的典型震颤形式,尤其是震颤为主型亚型,但帕金森病患者也可能出现姿势性震颤。在许多帕金森病患者中,这种姿势性震颤在几秒甚至几分钟的潜伏期后出现。在我们最初的描述中,我们创造了“再发性震颤”这个术语,以将这种姿势性震颤与特发性震颤区分开来,特发性震颤没有任何潜伏期,并且将其与PD静止性震颤联系起来,当采取新的握持姿势时,静止性震颤在经过一段时间潜伏期后会“重新启动”。这种再发性震颤与典型静止性震颤的关系得到了以下观察结果的支持:这种震颤与典型静止性震颤有许多共同特征,例如相同的3至5赫兹频率、偶尔的旋前-旋后成分以及对多巴胺能治疗的相对良好反应。很少见的情况下,即使没有明显的静止性震颤,也可以看到在短暂(2至4秒)潜伏期后出现的姿势性震颤。在大多数PD患者中,对他们来说,姿势性(再发性)震颤比典型的静止性震颤更麻烦,因为这种再发性震颤会干扰他们对抗重力握持物体(如报纸)的能力,并导致液体溢出。PD的姿势性震颤常被误诊为特发性震颤,当两种情况共存时,这种诊断挑战会进一步复杂化。当出现这种情况时,姿势性震颤没有潜伏期出现,尽管随着潜在的再发性震颤变得更加明显,其幅度可能会逐渐增加。