研究石蒜科植物L.的茎、花、鳞茎和果实提取物的抗增殖和抗氧化特性。
Investigating the Antiproliferative and Antioxidant Properties of L. (Amaryllidaceae) Stems, Flowers, Bulbs, and Fruits Extracts.
作者信息
Leporini Mariarosaria, Catinella Giorgia, Bruno Maurizio, Falco Tiziana, Tundis Rosa, Loizzo Monica R
机构信息
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy.
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Palermo, Italy.
出版信息
Evid Based Complement Alternat Med. 2018 Sep 30;2018:9301247. doi: 10.1155/2018/9301247. eCollection 2018.
Abstract
stems, flowers, bulbs, and fruits extracts were investigated for their antiproliferative and antioxidant properties. Total phenols and total flavonoids were also determined. The antiproliferative activity was tested against seven cancer cell lines such as C32, HeLa, MDA-MB-231, PC3, A549, MCF-7, and LNCaP by using SRB assay. Interesting results were obtained with stems ethanol extract (ET1) against C32 cells (IC of 27.1 g/mL) and fruits aqueous extract (AQ) against MCF-7 cell line (IC of 36.5 g/mL). To define the antioxidant activity, four tests such as DPPH, ABTS FRAP, and -carotene bleaching tests were used. The most promising ABTS scavenging capacity was observed with fruits ethanol extract (ET1) that showed an IC value of 6.9 g/mL. According to the correlation results, the phenols and flavonoids content could provide a fundamental contribution to the antioxidant and antiproliferative activity of extracts.
摘要
对茎、花、鳞茎和果实提取物的抗增殖和抗氧化特性进行了研究。还测定了总酚和总黄酮含量。通过SRB法对七种癌细胞系（如C32、HeLa、MDA-MB-231、PC3、A549、MCF-7和LNCaP）进行了抗增殖活性测试。茎乙醇提取物（ET1）对C32细胞（IC为27.1μg/mL）和果实水提取物（AQ）对MCF-7细胞系（IC为36.5μg/mL）获得了有趣的结果。为了确定抗氧化活性，使用了四种测试，如DPPH、ABTS、FRAP和β-胡萝卜素漂白测试。果实乙醇提取物（ET1）的ABTS清除能力最有前景，其IC值为6.9μg/mL。根据相关结果，酚类和黄酮类含量可为提取物的抗氧化和抗增殖活性提供重要贡献。
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