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本文引用的文献

1
Single tablet HIV regimens facilitate virologic suppression and retention in care among treatment naïve patients.单片剂抗HIV治疗方案有助于初治患者实现病毒学抑制并坚持治疗。
AIDS Care. 2018 Aug;30(8):1017-1024. doi: 10.1080/09540121.2018.1442554. Epub 2018 Feb 25.
2
Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.用于HIV抗逆转录病毒疗法的口服每周一次给药系统的研发。
Nat Commun. 2018 Jan 9;9(1):2. doi: 10.1038/s41467-017-02294-6.
3
Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial.长效肌内注射卡替拉韦和利匹韦林治疗成人 HIV-1 感染（LATTE-2）：一项随机、开放标签、2b 期、非劣效性试验的 96 周结果。
Lancet. 2017 Sep 23;390(10101):1499-1510. doi: 10.1016/S0140-6736(17)31917-7. Epub 2017 Jul 24.
4
Implementation challenges for long-acting antivirals as treatment.长效抗病毒药物作为治疗手段的实施挑战。
Curr Opin HIV AIDS. 2015 Jul;10(4):282-9. doi: 10.1097/COH.0000000000000158.
5
Pharmacokinetics of long-acting tenofovir alafenamide (GS-7340) subdermal implant for HIV prophylaxis.用于HIV预防的长效替诺福韦艾拉酚胺（GS-7340）皮下植入剂的药代动力学
Antimicrob Agents Chemother. 2015 Jul;59(7):3913-9. doi: 10.1128/AAC.00656-15. Epub 2015 Apr 20.
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Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials.降低HIV感染的药丸负担及每日一次抗逆转录病毒治疗方案：随机对照试验的荟萃分析
Clin Infect Dis. 2014 May;58(9):1297-307. doi: 10.1093/cid/ciu046. Epub 2014 Jan 22.
7
Increase in single-tablet regimen use and associated improvements in adherence-related outcomes in HIV-infected women.单一片剂方案使用率的增加以及与艾滋病病毒感染女性相关的与依从性相关结局的改善。
J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):587-96. doi: 10.1097/QAI.0000000000000082.
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Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
N Engl J Med. 2011 Aug 11;365(6):493-505. doi: 10.1056/NEJMoa1105243. Epub 2011 Jul 18.
9
Trust in physicians and racial disparities in HIV care.医患信任和 HIV 护理中的种族差异。
AIDS Patient Care STDS. 2010 Jul;24(7):415-20. doi: 10.1089/apc.2009.0288.
10
Racial differences in attitudes toward innovative medical technology.对创新医疗技术态度上的种族差异。
J Gen Intern Med. 2006 Jun;21(6):559-63. doi: 10.1111/j.1525-1497.2006.00453.x.

谁想换药？评估患者对新型抗逆转录病毒疗法的兴趣。

Who Wants to Switch? Gauging Patient Interest in Novel Antiretroviral Therapies.

作者信息

Derrick Caroline B, Ostermann Jan, Weissman Sharon B, Hobbie Amy, Alshareef Noor, Weinhold Andrew, Yelverton Valerie, Thielman Nathan M

机构信息

Department of Medicine, School of Medicine, University of South Carolina, Columbia, South Carolina.

Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.

出版信息

Open Forum Infect Dis. 2018 Oct 22;5(10):ofy247. doi: 10.1093/ofid/ofy247. eCollection 2018 Oct.

DOI:10.1093/ofid/ofy247
PMID:30364593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6197380/
Abstract

Study participants were asked about their interest in switching to novel drug delivery systems that reduce the dosing frequency of antiretroviral regimens. Across a diverse, treatment-experienced cohort, we describe greatest interest in switching to an oral regimen taken once weekly, followed by injections taken every other month and twice-annual implants.

摘要

研究参与者被问及他们对改用新型药物递送系统的兴趣，这些系统可减少抗逆转录病毒疗法的给药频率。在一个多样化的、有治疗经验的队列中，我们发现对改用每周服用一次的口服疗法兴趣最大，其次是每两个月注射一次和每年植入两次。