孤独与痴呆风险。
Loneliness and Risk of Dementia.
机构信息
Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee.
Euromov, University of Montpellier, France.
出版信息
J Gerontol B Psychol Sci Soc Sci. 2020 Aug 13;75(7):1414-1422. doi: 10.1093/geronb/gby112.
OBJECTIVE
The present study tests whether loneliness is associated with risk of dementia in the largest sample to date and further examines whether the association is independent of social isolation, a related but independent component of social integration, and whether it varies by demographic factors and genetic vulnerability.
METHOD
Participants from the Health and Retirement Study (N = 12,030) reported on their loneliness, social isolation, and had information on clinical, behavioral, and genetic risk factors. Cognitive status was assessed at baseline and every 2 years over a 10-year follow-up with the modified Telephone Interview for Cognitive Status (TICSm). A TICSm score of 6 or less was indicative of dementia.
RESULTS
Cox proportional hazards regression indicated that loneliness was associated with a 40% increased risk of dementia. This association held controlling for social isolation, and clinical, behavioral, and genetic risk factors. The association was similar across gender, race, ethnicity, education, and genetic risk.
DISCUSSION
Loneliness is associated with increased risk of dementia. It is one modifiable factor that can be intervened on to reduce dementia risk.
目的
本研究在迄今为止最大的样本中检验孤独感是否与痴呆风险相关，并进一步探讨这种相关性是否独立于社会隔离（社会融合的一个相关但独立的组成部分），以及是否受人口统计学因素和遗传易感性的影响。
方法
来自健康与退休研究（N=12030）的参与者报告了他们的孤独感和社会隔离情况，并提供了有关临床、行为和遗传风险因素的信息。认知状态在基线和 10 年的随访中每 2 年通过改良的电话认知状态测试（TICSm）进行评估。TICSm 得分为 6 或更低表示患有痴呆症。
结果
Cox 比例风险回归表明，孤独感与痴呆风险增加 40%相关。在控制社会隔离以及临床、行为和遗传风险因素后，这种相关性仍然存在。这种相关性在性别、种族、民族、教育和遗传风险方面相似。
讨论
孤独感与痴呆风险增加相关。它是一种可以干预的可改变的因素，可以降低痴呆风险。
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