McGhie I, Martin W, Tweddel A, Hutton I
Eur J Nucl Med. 1987;13(1):18-23. doi: 10.1007/BF00252640.
This study compared the accuracy of rest and exercise gated equilibrium technetium ventriculography with exercise thallium imaging in 50 consecutive male patients undergoing routine coronary angiography for the evaluation of chest pain. No patients were excluded on the basis of prior myocardial infarction, nature of angiographically defined coronary disease or symptoms. Antianginal therapy was continued in all patients. Eight patients had normal coronary arteries, 9 had single vessel, disease, 20 had double vessel disease and 13 had triple vessel disease. Sixteen patients had previously documented myocardial infarction. Using exercise radionuclide ventriculography, 34 patients with coronary disease were detected resulting in a sensitivity of 81%; 6 patients with normal coronary arteries had normal scans, a specificity of 75%, with a predictive accuracy of 80%. In comparison, thallium imaging detected 42 patients with coronary disease resulting in a sensitivity of 100%. Six patients with normal coronary arteries had normal thallium images resulting in a specificity of 75% and a predictive accuracy of 96%. These results suggest that exercise thallium imaging is a more accurate investigation than exercise equilibrium radio-nuclide ventriculography and is the investigation of choice in the noninvasive detection of coronary artery disease.
本研究比较了静息和运动门控平衡锝心室造影与运动铊显像在50例因胸痛接受常规冠状动脉造影的连续男性患者中的准确性。没有患者因既往心肌梗死、血管造影定义的冠状动脉疾病性质或症状而被排除。所有患者均继续进行抗心绞痛治疗。8例患者冠状动脉正常，9例为单支血管病变，20例为双支血管病变，13例为三支血管病变。16例患者既往有心肌梗死记录。使用运动放射性核素心室造影，检测出34例冠心病患者，敏感性为81%；6例冠状动脉正常的患者扫描结果正常，特异性为75%，预测准确性为80%。相比之下，铊显像检测出42例冠心病患者，敏感性为100%。6例冠状动脉正常的患者铊显像结果正常，特异性为75%，预测准确性为96%。这些结果表明，运动铊显像比运动平衡放射性核素心室造影更准确，是冠状动脉疾病无创检测的首选检查方法。
