非洛地平对慢性心力衰竭患者的持续血流动力学效应。
Sustained haemodynamic effects of felodipine in patients with chronic cardiac failure.
作者信息
Tweddel A C, Martin W, McGhie A I, Hutton I
机构信息
University Department of Medical Cardiology, Royal Infirmary, Glasgow.
出版信息
Br J Clin Pharmacol. 1988 Jun;25(6):689-94. doi: 10.1111/j.1365-2125.1988.tb05254.x.
Abstract
- The efficacy of felodipine a new calcium channel blocker with selective vasodilator activity in the management of severe low output cardiac failure, secondary to coronary heart disease, was determined in 10 patients. 2. Haemodynamic measurements were made at rest and during dynamic exercise and left ventricular function was assessed by radionuclide ventriculography. 3. Significant increases in cardiac index, stroke volume index and ejection fraction were found particularly during exercise, both acutely and following 4 weeks administration of felodipine therapy. 4. Felodipine could well have a significant role in the long term management of the patient with chronic cardiac failure.
摘要
- 对10例继发于冠心病的严重低输出量心力衰竭患者，测定了新型钙通道阻滞剂非洛地平（具有选择性血管扩张活性）的疗效。2. 在静息和动态运动时进行血流动力学测量，并通过放射性核素心室造影评估左心室功能。3. 发现心脏指数、每搏量指数和射血分数显著增加，尤其是在运动期间，无论是急性给药还是非洛地平治疗4周后。4. 非洛地平在慢性心力衰竭患者的长期管理中可能具有重要作用。
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1
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3
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4
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5
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6
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