Foresta C, Indino M, Manoni F, Scandellari C
Fertil Steril. 1987 Jun;47(6):1000-3. doi: 10.1016/s0015-0282(16)59236-x.
In this study, we demonstrated, by using known detergents, the presence of angiotensin-converting enzyme (ACE) within human spermatozoa. We determined that maximal angiotensin-converting activity is expressed by sperm incubated in capacitating conditions, whereas this activity is negligible in saline-incubated spermatozoa. We further demonstrated that not acrosomes but cytoplasmic residues contain ACE. Because follicular fluid provides the necessary conditions for a maximal angiotensin-converting activity and for capacitations' metabolic activation, we hypothesize that ACE may play its physiologic role within the female reproductive tract.
在本研究中，我们通过使用已知的去污剂，证实了人类精子中存在血管紧张素转换酶（ACE）。我们确定，在获能条件下孵育的精子表现出最大的血管紧张素转换活性，而在盐溶液中孵育的精子中这种活性可忽略不计。我们进一步证明，含有ACE的不是顶体，而是细胞质残余物。由于卵泡液为最大的血管紧张素转换活性和获能的代谢激活提供了必要条件，我们推测ACE可能在女性生殖道中发挥其生理作用。
