Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Curr Opin Microbiol. 2018 Dec;46:109-115. doi: 10.1016/j.mib.2018.10.002. Epub 2018 Oct 23.
Plasmodium vivax is uniquely restricted to invading reticulocytes, the youngest of red blood cells. Parasite invasion relies on the sequential deployment of multiple parasite invasion ligands. Correct targeting of the host reticulocyte is mediated by two families of invasion ligands: the reticulocyte binding proteins (RBPs) and erythrocyte binding proteins (EBPs). The Duffy receptor has long been established as a key determinant for P. vivax invasion. However, recently, the RBP protein PvRBP2b has been shown to bind to transferrin receptor, which is expressed on reticulocytes but lost on normocytes, implicating the ligand-receptor in the reticulocyte tropism of P. vivax. Furthermore there is increasing evidence for P. vivax growth and sexual development in reticulocyte-enriched tissues such as the bone marrow.
间日疟原虫(P. vivax) 是唯一能入侵网织红细胞的疟原虫，网织红细胞是红细胞中最年轻的细胞。寄生虫的入侵依赖于多种寄生虫入侵配体的顺序部署。宿主网织红细胞的正确靶向是由两类入侵配体介导的：网织红细胞结合蛋白（RBP）和红细胞结合蛋白（EBP）。Duffy 受体一直被认为是间日疟原虫入侵的关键决定因素。然而，最近的研究表明，RBP 蛋白 PvRBP2b 可以与转铁蛋白受体结合，转铁蛋白受体仅在网织红细胞上表达，而在正常红细胞上丢失，这表明配体-受体在间日疟原虫的网织红细胞嗜性中起作用。此外，越来越多的证据表明间日疟原虫在富含网织红细胞的组织（如骨髓）中生长和有性发育。
