果蝇中黄嘌呤脱氢酶结构基因（玫瑰色基因座）的序列。
Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster.
作者信息
Keith T P, Riley M A, Kreitman M, Lewontin R C, Curtis D, Chambers G
出版信息
Genetics. 1987 May;116(1):67-73. doi: 10.1093/genetics/116.1.67.
Abstract
We determined the nucleotide sequence of a 4.6-kb EcoRI fragment containing 70% of the rosy locus. In combination with information on the 5' sequence, the gene has been sequenced in entirety. rosy cDNAs have been isolated and intron/exon boundaries have been determined. We find an open reading frame which spans four exons and would encode a protein of 1335 amino acids. The molecular weight of the encoded protein (xanthine dehydrogenase), based on the amino acid translation, is 146,898 daltons which agrees well with earlier biophysical estimates. Characteristics of the protein are discussed.
摘要
我们测定了一个包含玫瑰色基因座70%的4.6kb EcoRI片段的核苷酸序列。结合5'端序列信息，该基因已被完整测序。玫瑰色基因的cDNA已被分离出来，内含子/外显子边界也已确定。我们发现一个开放阅读框，它跨越四个外显子，编码一个1335个氨基酸的蛋白质。根据氨基酸翻译结果，编码蛋白（黄嘌呤脱氢酶）的分子量为146,898道尔顿，这与早期的生物物理估计结果非常吻合。文中还讨论了该蛋白的特性。
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