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1
Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster.果蝇中黄嘌呤脱氢酶结构基因（玫瑰色基因座）的序列。
Genetics. 1987 May;116(1):67-73. doi: 10.1093/genetics/116.1.67.
2
Developmental regulation of the rosy locus in Drosophila melanogaster.黑腹果蝇中 rosy 基因座的发育调控
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3
Mutations affecting expression of the rosy locus in Drosophila melanogaster.影响黑腹果蝇中玫瑰色基因座表达的突变。
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4
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5
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6
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本文引用的文献

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Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing.DNA测序鸟枪法产生的凝胶读数数据的计算机处理自动化。
Nucleic Acids Res. 1982 Aug 11;10(15):4731-51. doi: 10.1093/nar/10.15.4731.
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Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster.通过染色体步移和跳查从黑腹果蝇的Ace和玫瑰色基因座以及双胸复合体中分离DNA。
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Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.利用寡脱氧核苷酸定向诱变构建改良的M13载体。
Gene. 1983 Dec;26(1):101-6. doi: 10.1016/0378-1119(83)90040-9.
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pEMBL: a new family of single stranded plasmids.pEMBL：一类新型单链质粒。
Nucleic Acids Res. 1983 Mar 25;11(6):1645-55. doi: 10.1093/nar/11.6.1645.
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Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.利用单链噬菌体克隆辅助快速DNA测序。
J Mol Biol. 1980 Oct 25;143(2):161-78. doi: 10.1016/0022-2836(80)90196-5.
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Tissue-specific and pretranslational character of variants of the rosy locus control element in Drosophila melanogaster.黑腹果蝇中玫瑰色基因座控制元件变体的组织特异性和翻译前特征。
Genetics. 1984 Dec;108(4):953-68. doi: 10.1093/genetics/108.4.953.
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Studies on gene conversion and its relationship to linked exchange in Drosophila melanogaster.黑腹果蝇中基因转换及其与连锁交换关系的研究。
Genetics. 1971 Oct;69(2):179-209. doi: 10.1093/genetics/69.2.179.
9
Intracistronic mapping of electrophoretic sites in Drosophila melanogaster: fidelity of information transfer by gene conversion.黑腹果蝇电泳位点的顺反子内图谱绘制：基因转换信息传递的保真度
Genetics. 1974 Feb;76(2):289-99. doi: 10.1093/genetics/76.2.289.
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Signal sequences. The limits of variation.信号序列。变异的限度。
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果蝇中黄嘌呤脱氢酶结构基因（玫瑰色基因座）的序列。

Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster.

作者信息

Keith T P, Riley M A, Kreitman M, Lewontin R C, Curtis D, Chambers G

出版信息

Genetics. 1987 May;116(1):67-73. doi: 10.1093/genetics/116.1.67.

DOI:10.1093/genetics/116.1.67
PMID:3036646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1203122/
Abstract

We determined the nucleotide sequence of a 4.6-kb EcoRI fragment containing 70% of the rosy locus. In combination with information on the 5' sequence, the gene has been sequenced in entirety. rosy cDNAs have been isolated and intron/exon boundaries have been determined. We find an open reading frame which spans four exons and would encode a protein of 1335 amino acids. The molecular weight of the encoded protein (xanthine dehydrogenase), based on the amino acid translation, is 146,898 daltons which agrees well with earlier biophysical estimates. Characteristics of the protein are discussed.

摘要

我们测定了一个包含玫瑰色基因座70%的4.6kb EcoRI片段的核苷酸序列。结合5'端序列信息，该基因已被完整测序。玫瑰色基因的cDNA已被分离出来，内含子/外显子边界也已确定。我们发现一个开放阅读框，它跨越四个外显子，编码一个1335个氨基酸的蛋白质。根据氨基酸翻译结果，编码蛋白（黄嘌呤脱氢酶）的分子量为146,898道尔顿，这与早期的生物物理估计结果非常吻合。文中还讨论了该蛋白的特性。