von Heijne G
J Mol Biol. 1985 Jul 5;184(1):99-105. doi: 10.1016/0022-2836(85)90046-4.
Variations in length and composition of the charged N-terminal, central hydrophobic and polar C-terminal regions in a large sample of signal sequences have been mapped, both as a function of the overall length of the sequence, and in an absolute sense, i.e. various "extremes" have been sought. The results show subtle differences between eukaryotic and prokaryotic sequences, but the general impression of signal sequences as being highly variable is reinforced. Criteria for a "minimal" signal sequence are suggested and discussed.
在大量信号序列样本中，已绘制出带电荷的N端、中央疏水区域和极性C端区域的长度及组成变化情况，这既是序列总长度的函数，也是从绝对意义上而言，即已找出各种“极端情况”。结果显示真核生物和原核生物序列之间存在细微差异，但信号序列高度可变这一总体印象得到了强化。文中提出并讨论了“最小”信号序列的标准。
