Liaoning Key Laboratory of Pulp and Paper Engineering, Dalian Polytechnic University, 1#Ganjingzi District, Dalian, 116034, China.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, No. 100, Martyrs Middle Road, Yuexiu District, Guangzhou, 510070, China.
Carbohydr Polym. 2019 Jan 15;204:214-222. doi: 10.1016/j.carbpol.2018.10.020. Epub 2018 Oct 9.
Cationic amphiphilic cellulose copolymers were prepared through grafting hydrophobic poly (p-dioxanone) (PPDO) chains onto hydrophilic quaternized cellulose derivatives (QC) via ring-opening polymerization (ROP) reaction, which was performed in 1-butyl-3-methylimidazolium chloride (BmimCl) and using 4-dimethylaminopyridine (DMAP) or 1,8-diazabicyclo (5.4.0) undec-7-ene (DBU) as catalyst. Their chemical structures and physical properties were confirmed by FT-IR, H-, C-, 2D HSQC-NMR, X-ray diffraction (XRD), and thermal stability (TGA) techniques, while self-assembly behavior was characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM) and fluorescence techniques. Both of the sizes and critical micelle concentration (CMC) values of micelles were decreased with increasing grafting contents of PPDO in the copolymers, which were in the ranges of 110-246 nm and 64-253 μg/mL, respectively. The ζ-potentials of micelles were cationic andranged from 39.1 mV to 45.4 mV. The highest encapsulation efficiencyof paclitaxel (PTX) into the micelles was 61.8% and 92.0% of loaded PTX was continuously released from micelles in phosphate buffered saline medium for 36 h.
阳离子两亲性纤维素共聚物是通过在亲水季铵化纤维素衍生物（QC）上接枝疏水性聚（对二氧环己酮）（PPDO）链，通过开环聚合（ROP）反应制备的，该反应在 1-丁基-3-甲基咪唑氯（BmimCl）中进行，并使用 4-二甲氨基吡啶（DMAP）或 1,8-二氮杂二环（5.4.0）十一-7-烯（DBU）作为催化剂。通过傅里叶变换红外光谱（FT-IR）、H-、C-、二维 HSQC-NMR、X 射线衍射（XRD）和热稳定性（TGA）技术确认了它们的化学结构和物理性质，而自组装行为则通过动态光散射（DLS）、透射电子显微镜（TEM）和荧光技术进行了表征。共聚物中 PPDO 的接枝含量增加，胶束的粒径和临界胶束浓度（CMC）值均降低，分别在 110-246nm 和 64-253μg/mL 范围内。胶束的 ζ-电位为正电性，范围从 39.1mV 到 45.4mV。紫杉醇（PTX）的最高包封效率为 61.8%，负载的 PTX 在磷酸盐缓冲盐水介质中 36h 内持续释放 92.0%。
