Hussman Institute for Autism, 801W. Baltimore St., Suite 301, Baltimore, MD, 21201, USA.
Pediatr Res. 2019 Jan;85(2):146-154. doi: 10.1038/s41390-018-0214-6. Epub 2018 Oct 26.
Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC. Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC.
皮质中间神经元（INs）是一大类神经元，它们在大脑中局部投射并塑造神经网络的功能。多条证据表明，谷氨酸和 GABA 信号的适当平衡对于大脑的正常功能和发育都是必不可少的。该系统的失调可能导致神经发育障碍，包括自闭症谱系条件（ASC）。我们评估了啮齿动物和人类模型中 INs 的发育和功能，并研究了神经发育功能障碍如何产生 ASC 的核心症状。发现神经发育障碍的共同生理机制可能会导致新的药理学靶点和候选药物，从而改善与 ASC 相关的认知和情绪症状。
