不同高通量透析器在后稀释在线血液透析滤过过程中的清除能力。

Removal capacity of different high-flux dialyzers during postdilution online hemodiafiltration.

作者信息

Santos García Alba, Macías Carmona Nicolás, Vega Martínez Almudena, Abad Estébanez Soraya, Linares Grávalos Tania, Aragoncillo Sauco Inés, Verdalles Guzmán Ursula, Panizo González Nayara, Cruzado Vega Leonidas, López Gómez Juan Manuel

机构信息

Nephrology Department, Hospital Gregorio Marañón, Madrid, Spain.

Nephrology Department, Hospital Universitario de Elche, Alicante, Spain.

出版信息

Hemodial Int. 2019 Jan;23(1):50-57. doi: 10.1111/hdi.12685. Epub 2018 Oct 27.

DOI:10.1111/hdi.12685

PMID:30367698

Abstract

INTRODUCTION

The aim of this study is to compare molecule removal and albumin leakage in postdilution online hemodiafiltration with different high-flux dialyzers.

METHODS

We studied seven high-flux dialyzers (Polyflux 210H®, Evodial 2.2®, FxCordiax1000®, Elisio21H®, TS-2.1SL®, XevontaHi20®, VitaPES 210-HF®) in 6 patients. The reduction ratio (RR) of small- and middle-sized molecules was calculated. Dialysate samples were collected to estimate the albumin leakage.

FINDINGS

Global differences between dialyzers were observed in the RR of ß2 microglobulin (P =0.003) and prolactin (P =0.013). The mean loss of albumin in the dialysate per session varied between 114 ± 67 mg (with Evodial 2.2) and 2621 ± 1363 mg per session (with XevontaHi20). We found global differences between dialyzers in total albumin loss (P = 0.05).

DISCUSSION

We demonstrated that the performance of high-flux dialyzers was different among the types and that not all high-flux dialyzers should be considered equal.

摘要

引言

本研究旨在比较不同高通量透析器在后置稀释在线血液透析滤过中的分子清除率及白蛋白漏出情况。

方法

我们对6例患者使用7种高通量透析器（Polyflux 210H®、Evodial 2.2®、FxCordiax1000®、Elisio21H®、TS - 2.1SL®、XevontaHi20®、VitaPES 210 - HF®）进行研究。计算小分子和中分子的清除率（RR）。收集透析液样本以评估白蛋白漏出情况。

结果

观察到不同透析器之间在β2微球蛋白清除率（P = 0.003）和催乳素清除率（P = 0.013）方面存在总体差异。每次透析过程中透析液中白蛋白的平均丢失量在114±67毫克（使用Evodial 2.2时）至每次2621±1363毫克（使用XevontaHi20时）之间。我们发现不同透析器在白蛋白总丢失量方面存在总体差异（P = 0.05）。