Gerontology Department (GERO), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium; Frailty in Aging Research Group (FRIA), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Gerontology Department (GERO), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium; Frailty in Aging Research Group (FRIA), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium.
Exp Gerontol. 2018 Dec;114:33-49. doi: 10.1016/j.exger.2018.10.011. Epub 2018 Oct 25.
Ageing-related low-grade inflammation is suggested to aggravate sarcopenia and frailty. This systematic review investigates the influence that drugs with anti-inflammatory effects (AIDs) have on inflammation and skeletal muscle.
PubMed and Web of Science were systematically screened for articles reporting the effects of AIDs on inflammation on one hand and on muscle mass and/or performance on the other.
Twenty-eight articles were included. These articles were heterogeneous in terms of the subjects studied, intervention components, setting, and outcome measures. Articles on older humans with acute inflammation showed evidence that celecoxib and piroxicam could reduce inflammation and improve performance and that ibuprofen improves exercise-induced muscle hypertrophy and gains in strength. In younger humans, only the effects of AIDs combined with exercise were investigated; no significant benefits of non-selective COX-inhibitors were reported, but improved strength gains with etanercept and reduced muscle soreness with celecoxib were noted. Indomethacin increased acute exercise-induced inflammation and reduced satellite cell differentiation in exercising muscle. Most articles did not systematically report occurrences of side effects.
Although AIDs showed significant reduction in inflammation-induced muscle weakness in older hospitalised patients with acute inflammation, robust evidence is still lacking. When combined with exercise, AIDs presented a protective effect against age-related loss of muscle mass, thus enhancing muscle mass and performance. The mechanism regulating muscle strength and its mass seems to differ between individuals of old and young age. However, the effects seem drug-specific and dose-dependent and appear to be influenced by subjects' trainability and the clinical context. In addition, the balance between benefits and harm remains unclear.
与衰老相关的低度炎症被认为会加重肌肉减少症和虚弱。本系统评价调查了具有抗炎作用的药物（AIDs）对炎症和骨骼肌的影响。
系统检索了 PubMed 和 Web of Science 中关于 AIDs 对炎症影响以及对肌肉质量和/或性能影响的文章。
共纳入 28 篇文章。这些文章在研究对象、干预成分、环境和结果测量方面存在异质性。针对急性炎症老年人群的研究表明，塞来昔布和吡罗昔康可降低炎症、改善运动表现，而布洛芬可改善运动引起的肌肉肥大和力量增强。在年轻人群中，仅研究了 AIDs 与运动相结合的效果；未报告非选择性 COX 抑制剂的显著益处，但发现依那西普可增强力量增益，塞来昔布可减轻肌肉酸痛。吲哚美辛可增加急性运动引起的炎症，并减少运动肌肉中的卫星细胞分化。大多数文章没有系统地报告副作用的发生。
尽管 AIDs 可显著减轻急性炎症老年住院患者的炎症性肌肉无力，但仍缺乏有力证据。当与运动相结合时，AIDs 对与年龄相关的肌肉质量损失具有保护作用，从而增强肌肉质量和性能。调节肌肉力量及其质量的机制在老年和年轻个体之间似乎存在差异。然而，这些效果似乎是药物特异性和剂量依赖性的，并且似乎受到受试者的可训练性和临床环境的影响。此外，获益与危害之间的平衡仍不清楚。
