Jinzhou Medical University, Jinzhou, 121001, China.
Jinzhou Medical University, Jinzhou, 121001, China.
Colloids Surf B Biointerfaces. 2019 Jan 1;173:654-661. doi: 10.1016/j.colsurfb.2018.10.037. Epub 2018 Oct 17.
Developing safe and effective stimuli-responsive nanocarriers is very important for tumor chemotherapy. In this work, bovine serum albumin (BSA) and green tea polyphenol (TP) were used to prepare glutathione (GSH) and enzyme (trypsin) responsive nanocarriers for doxorubicin (DOX). These nanocarriers were further modified with folate, briefly named as DOX@BSA-TP-FA NSs. The diameter of nanocarriers was about 220 nm. The DOX loading efficiency and loading amount were 86.4% and 23.5 wt%, respectively. The cellular uptake, apoptosis, and GSH and trypsin responsive release properties of these nanocarriers were investigated.
开发安全有效的刺激响应型纳米载体对于肿瘤化疗非常重要。在这项工作中，牛血清白蛋白（BSA）和绿茶多酚（TP）被用于制备谷胱甘肽（GSH）和酶（胰蛋白酶）响应的阿霉素（DOX）纳米载体。这些纳米载体进一步用叶酸进行修饰，简称为 DOX@BSA-TP-FA NSs。纳米载体的直径约为 220nm。DOX 的载药效率和载药量分别为 86.4%和 23.5wt%。研究了这些纳米载体的细胞摄取、凋亡以及 GSH 和胰蛋白酶响应的释放特性。
