Elbagory Abdulrahman M, Marima Rahaba Makgotso, Dlamini Zodwa
SAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Pretoria 0028, South Africa.
Cancers (Basel). 2021 Nov 13;13(22):5686. doi: 10.3390/cancers13225686.
The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These "smart" vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking the potential toxicity into consideration, the incorporation of natural "green" materials, derived from plants or microbial sources, in the nanocarriers fabrication, improve their safety and biocompatibility. These green components can be used as a mechanical platform or as targeting ligand for the payload or can play a role in the synthesis of nanoparticles. Several studies reported the use of green based nanocarriers for the treatment of diseases such as cancer. This review article provides a critical analysis of the different types of green nanocarriers and their synthesis mechanisms, characterization, and their role in improving drug delivery of anticancer drugs to achieve precision cancer treatment. Current evidence suggests that green-based nanocarriers can constitute an effective treatment against cancer.
纳米载体在生物医学应用中的使用已引起全球研究人员的兴趣，用于以可控方式递送治疗剂。这些“智能”载体可提高药物的溶解度和生物利用度，并使其能够递送至靶位点。考虑到潜在的毒性，在纳米载体制造中加入源自植物或微生物来源的天然“绿色”材料，可提高其安全性和生物相容性。这些绿色成分可作为机械平台或作为有效载荷的靶向配体，或可在纳米颗粒的合成中发挥作用。多项研究报道了使用基于绿色材料的纳米载体治疗癌症等疾病。这篇综述文章对不同类型的绿色纳米载体及其合成机制、表征以及它们在改善抗癌药物递送以实现精准癌症治疗方面的作用进行了批判性分析。目前的证据表明，基于绿色材料的纳米载体可构成一种有效的癌症治疗方法。
