Demmler G J, Yow M D, Spector S A, Reis S G, Brady M T, Anderson D C, Taber L H
J Infect Dis. 1987 Jul;156(1):9-16. doi: 10.1093/infdis/156.1.9.
Using serology, virology, and molecular epidemiology, we investigated nosocomial transmission of cytomegalovirus (CMV) over a two-year period in two contrasting environments: a crowded, busy pediatric chronic care unit (337 patients, 43 nurses, and 76 therapists; average prevalence of CMV excretion in patients, 16%) and a small neonatal unit (293 patients and 69 nurses; average prevalence, 0.7%). In the chronic care unit no nurse or therapist acquired CMV, but two pairs of infants were infected with homologous strains of CMV, and patient-to-patient transmission was proven in one pair. In the neonatal unit no patients acquired CMV in the hospital, but two nurses seroconverted, with a nonoccupational source proven for one. Transmission from CMV-infected caretaker to patient did not occur in either environment. CMV was isolated from diapers as well as hands of patients and personnel but not from other environmental surfaces.
我们运用血清学、病毒学和分子流行病学方法，在两年时间里，对两种截然不同的环境中医院内巨细胞病毒（CMV）的传播情况进行了调查：一个是拥挤繁忙的儿科慢性病护理病房（有337名患者、43名护士和76名治疗师；患者中CMV排泄的平均患病率为16%），另一个是小型新生儿病房（有293名患者和69名护士；平均患病率为0.7%）。在慢性病护理病房，没有护士或治疗师感染CMV，但有两对婴儿感染了同源性CMV毒株，且在其中一对中证实存在患者之间的传播。在新生儿病房，没有患者在医院内感染CMV，但有两名护士血清学转换，其中一人的感染源被证实为非职业性的。在这两种环境中，均未发生从CMV感染的护理人员到患者的传播。CMV从尿布以及患者和工作人员的手上分离出来，但未从其他环境表面分离出来。
