Zhdanov Renad Ibrahimovich, Kupriyanov Roman Vladimirovich, Zhdanova Svetlana Igorevna, Dvoenosov Vladimir Georgievich
1"Healthy Food" Open Laboratory, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 74, Karl Marx St., Kazan, Russian Federation 420008.
2Russin Institute for Advanced Study, Moscow State Pedagogical University, 1/1, Malaya Pirogovskaya St., Moscow, Russian Federation 119991.
Indian J Hematol Blood Transfus. 2018 Oct;34(4):727-730. doi: 10.1007/s12288-018-0980-7. Epub 2018 Jul 6.
This work aims to clarify how blood coagulation parameters reflect mild stress response in males and females. Healthy student volunteers of both sexes were used in this pilot study. A new global sensitive assay of haemostasis, spatial thrombodynamics, along with conventional coagulometry approach were used to evaluate of blood coagulation parameters. Psychodiagnostics scales (according to Spielberger and Taylor) are employed to evaluate anxiety as stress-induced response. We have selected exam stress, which despite being a mild stressor may nevertheless cause somatic disorders. We provide the first evidence of a statistically significant increase in initial clot growth velocity in women, but not men, in response to exam stress. The exam situation produces higher situational anxiety in female volunteers, and so they express remarkable stress-induced haemostatic responses, including plasma- and platelet-based changes. In contrast, male volunteers do not express pronounced stress-induced changes in haemostasis, and only display a decrease in plateletcrit value and an increase in prothrombin time. Mild form of stress (exam) induces changes in some blood coagulation parameters. A statistically significant remarkable increase in V value and some other plasma- and platelet-based parameters has been seen in female students (but not male ones) under exam stress.
这项工作旨在阐明血液凝固参数如何反映男性和女性的轻度应激反应。本初步研究使用了健康的男女学生志愿者。一种新的全球敏感止血检测方法——空间血栓动力学，以及传统的凝血测定方法，被用于评估血液凝固参数。心理诊断量表（根据斯皮尔伯格和泰勒编制）用于评估作为应激诱导反应的焦虑。我们选择了考试应激，尽管它是一种轻度应激源，但仍可能导致躯体障碍。我们首次提供了证据，表明女性（而非男性）在应对考试应激时，初始凝块生长速度有统计学意义的显著增加。考试情境在女性志愿者中产生了更高的情境焦虑，因此她们表现出显著的应激诱导止血反应，包括基于血浆和血小板的变化。相比之下，男性志愿者在止血方面没有表现出明显的应激诱导变化，仅显示血小板压积值降低和凝血酶原时间增加。轻度应激形式（考试）会引起一些血液凝固参数的变化。在考试应激下，女学生（而非男学生）的V值以及其他一些基于血浆和血小板的参数有统计学意义的显著增加。
