Asadpour Abdoreza, Alavi Ali, Jahed Mehran, Mahmoudian Saeid
Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
ENT and Head & Neck Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Front Integr Neurosci. 2018 Oct 12;12:48. doi: 10.3389/fnint.2018.00048. eCollection 2018.
About 20 percent of people above 60 years old suffer from tinnitus though no definitive treatment has been found for it. Evaluation of electrical brain activity using Event-Related Potentials (ERPs) is one of the methods to investigate the underlying reasons of tinnitus perception. Previous studies using ERPs suggest that the precognitive memory in tinnitus groups is negatively affected in comparison to the normal hearing groups. In this study, cognitive memory has been assessed using visual and auditory P300 response with oddball paradigm. Fifteen chronic tinnitus subjects and six normal hearing subjects participated in the experiment. -test with significance level of 0.05 was applied on amplitude and latency of auditory and visual P300 for all electroencephalography (EEG) channels separately to compare tinnitus and normal hearing groups where the tinnitus group showed meaningful lower amplitude of auditory P300 peak in three EEG channels.
60岁以上的人群中约20%患有耳鸣,尽管尚未找到针对耳鸣的确切治疗方法。使用事件相关电位(ERP)评估脑电活动是探究耳鸣感知潜在原因的方法之一。以往使用ERP的研究表明,与听力正常的人群相比,耳鸣人群的认知前记忆受到负面影响。在本研究中,采用视觉和听觉P300反应的oddball范式评估认知记忆。15名慢性耳鸣受试者和6名听力正常的受试者参与了实验。分别对所有脑电图(EEG)通道的听觉和视觉P300的振幅和潜伏期应用显著性水平为0.05的t检验,以比较耳鸣组和听力正常组,耳鸣组在三个EEG通道中听觉P300峰值的振幅明显较低。