Lalanne Txomin, Oyrer Julia, Farrant Mark, Sjöström P Jesper
Department of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Front Synaptic Neurosci. 2018 Oct 12;10:34. doi: 10.3389/fnsyn.2018.00034. eCollection 2018.
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.
已知钙通透（CP）型α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体介导多种不同类型中间神经元（IN）的突触可塑性。最近的证据表明，CP-AMPA受体在海马体和新皮质中特定类型的兴奋性连接上以突触特异性方式表达。例如，在从锥体细胞（PC）到篮状细胞（BC）的连接中发现了CP-AMPA受体，但在到马丁诺蒂细胞（MC）的连接中未发现。CP-AMPA受体的这种突触类型特异性表达表明，突触动力学以及学习规则在局部回路中以不同方式实现，不仅对健康有重要意义，对癫痫等疾病状态也有重要意义。
