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溶液中颗粒的表征——光散射及相关技术综述

Characterisation of particles in solution - a perspective on light scattering and comparative technologies.

作者信息

Maguire Ciarán Manus, Rösslein Matthias, Wick Peter, Prina-Mello Adriele

机构信息

Laboratory for Biological Characterisation of Advanced Materials (LBCAM), Department of Clinical Medicine, Trinity Translational Medicine Institute (TTMI), School of Medicine, Trinity College Dublin, Dublin, Ireland.

AMBER Centre, CRANN Institute, Trinity College Dublin, Dublin, Ireland.

出版信息

Sci Technol Adv Mater. 2018 Oct 18;19(1):732-745. doi: 10.1080/14686996.2018.1517587. eCollection 2018.

DOI:10.1080/14686996.2018.1517587
PMID:30369998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6201793/
Abstract

We present here a perspective detailing the current state-of-the-art technologies for the characterisation of nanoparticles (NPs) in liquid suspension. We detail the technologies involved and assess their applications in the determination of NP size and concentration. We also investigate the parameters that can influence the results and put forward a cause and effect analysis of the principle factors influencing the measurement of NP size and concentration by NP tracking analysis and dynamic light scattering, to identify areas where uncertainties in the measurement can arise. Also included are technologies capable of characterising NPs in solution, whose measurements are not based on light scattering. It is hoped that the manuscript, with its detailed description of the methodologies involved, will assist scientists in selecting the appropriate technology for characterising their materials and enabling them to comply with regulatory agencies' demands for accurate and reliable NP size and concentration data.

摘要

我们在此呈现一篇综述,详述了用于表征液体悬浮液中纳米颗粒(NP)的当前先进技术。我们详细介绍了所涉及的技术,并评估了它们在确定NP尺寸和浓度方面的应用。我们还研究了可能影响结果的参数,并对影响NP跟踪分析和动态光散射测量NP尺寸和浓度的主要因素进行了因果分析,以确定测量中可能出现不确定性的领域。此外还包括能够表征溶液中NP的技术,其测量并非基于光散射。希望这篇对所涉及方法进行详细描述的论文,能帮助科学家选择合适的技术来表征他们的材料,并使其能够满足监管机构对准确可靠的NP尺寸和浓度数据的要求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/151644d1c53d/TSTA_A_1517587_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/a2eafe939b4c/TSTA_A_1517587_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/9016eda8ec8e/TSTA_A_1517587_F0001_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/a0718b5ae3e6/TSTA_A_1517587_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/586dfe1c6009/TSTA_A_1517587_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/aaa32106ff14/TSTA_A_1517587_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/176a94810724/TSTA_A_1517587_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/1b99e3d01225/TSTA_A_1517587_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/2c47eae93d08/TSTA_A_1517587_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/151644d1c53d/TSTA_A_1517587_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/a2eafe939b4c/TSTA_A_1517587_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/9016eda8ec8e/TSTA_A_1517587_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/abe359615217/TSTA_A_1517587_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/616c5db3db81/TSTA_A_1517587_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/a0718b5ae3e6/TSTA_A_1517587_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/586dfe1c6009/TSTA_A_1517587_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/aaa32106ff14/TSTA_A_1517587_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/176a94810724/TSTA_A_1517587_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/1b99e3d01225/TSTA_A_1517587_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/2c47eae93d08/TSTA_A_1517587_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9182/6201793/151644d1c53d/TSTA_A_1517587_F0010_OC.jpg

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Nanomedicine (Lond). 2018 Mar 1;13(5):539-554. doi: 10.2217/nnm-2017-0338. Epub 2018 Jan 30.
3
Asymmetrical flow field flow fractionation methods to characterize submicron particles: application to carbon-based aggregates and nanoplastics.
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Vaccines (Basel). 2025 Jun 27;13(7):701. doi: 10.3390/vaccines13070701.
4
Evaluating the Efficiency of Enhanced Coagulation for Nanoplastics Removal Using Flow Cytometry.使用流式细胞术评估强化混凝去除纳米塑料的效率。
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5
Process Analytical Strategies for Size Monitoring: Offline, At-Line, Online, and Inline Methods in a Top-Down Nano-Manufacturing Line.尺寸监测的过程分析策略:自上而下的纳米制造生产线中的离线、在线、联机和在线方法
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6
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7
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Sci Rep. 2025 May 29;15(1):18914. doi: 10.1038/s41598-025-04433-2.
8
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9
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6
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7
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8
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9
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