National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Unit of Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Contact Dermatitis. 2019 Feb;80(2):86-93. doi: 10.1111/cod.13136. Epub 2018 Oct 29.
Knowledge about the skin deposition and penetration of nickel into the stratum corneum (SC) after short contact with metallic items is limited.
To quantify nickel skin deposition and penetration into the SC after short contact with metallic nickel.
Sixteen nickel-allergic participants and 10 controls were exposed to 3 pure nickel discs and 1 aluminium disc on each volar forearm for 3 × 10 minutes. Before exposure, 1 forearm was irritated with 0.5% sodium lauryl sulfate under 24-hour occlusion. Immediately, as well as 24 and 72 hours after metallic disc exposure, outer SC layers were removed with adhesive tapes and the nickel content was measured.
Nickel deposition and SC penetration capable of eliciting allergic nickel dermatitis were found immediately and after 24 hours. Significantly higher nickel amounts were found on normal skin and in the SC of nickel-allergic participants than in controls both immediately and after 24 hours, and on irritated skin immediately after exposure.
Nickel deposition and SC penetration is considerable after nickel skin exposure of 3 × 10 minutes. Combined with the allergic responses resulting from the same exposures reported previously, this study highlights that short skin exposure to nickel-releasing items may cause allergic nickel dermatitis.
关于金属物品短时间接触后镍在角质层（SC）中的沉积和渗透的知识有限。
定量研究金属镍短时间接触后镍在 SC 中的沉积和渗透。
16 名镍过敏参与者和 10 名对照者在每个前臂掌侧分别暴露于 3 个纯镍盘和 1 个铝盘，每个盘接触 10 分钟，共 3 次。暴露前，前臂用 0.5%十二烷基硫酸钠封闭 24 小时进行刺激。在金属盘暴露后即刻、24 小时和 72 小时，用粘性胶带去除外层 SC 层，并测量镍含量。
即刻和 24 小时后均发现有能力引发镍过敏性皮炎的镍沉积和 SC 渗透。与对照组相比，镍过敏参与者的正常皮肤和 SC 中即刻和 24 小时后以及暴露后即刻的镍含量均明显更高，在刺激皮肤后即刻的镍含量更高。
镍在 3×10 分钟的镍皮肤暴露后会有可观的沉积和渗透。结合先前报道的相同暴露所引起的过敏反应，本研究表明，短时间的皮肤接触释放镍的物品可能会导致镍过敏性皮炎。
