Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Department of Nephrology, Loyola University Medical Center, Maywood, IL, USA.
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):269S-276S. doi: 10.1177/1076029618808909. Epub 2018 Oct 28.
Atrial fibrillation (AF) is prevalent in nearly 27% of patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD), suggesting a strong association between these 2 pathologies. It is hypothesized that the relationship between these 2 diseases may be mediated by inflammation. Angiopoietin-2 (Ang-2), a pro-inflammatory biomarker of endothelial instability, inflammation, and vascular remodeling, is elevated in CKD5-HD and AF, yet has not been evaluated in patients with concomitant AF and CKD5-HD. The aim of this study is to analyze circulating levels of inflammatory and thrombotic biomarkers in patients with concomitant AF and CKD5-HD. Plasma levels of Ang-2 were measured via sandwich enzyme-linked immunosorbent assay method in CKD5-HD patients (n = 96), patients with AF (n = 38), and controls (n = 50). Angiopoietin-2 was markedly elevated in CKD5-HD with comorbid AF as compared to CKD5-HD alone, and AF alone, respectively (13.05 ± 1.56 vs 9.57 ± 0.71 ng/mL; = .00169; vs 2.48 ± 0.57 ng/mL; < .0001). The results of this study suggest an additive effect of Ang-2 with coexistence of AF and CKD5-HD, which may be useful in the detection of AF within this patient population.
心房颤动（AF）在接受血液透析（CKD5-HD）的 5 期慢性肾脏病（CKD5-HD）患者中患病率接近 27%，提示这两种病理之间存在很强的关联。据推测，这两种疾病之间的关系可能通过炎症来介导。血管生成素-2（Ang-2）是内皮不稳定、炎症和血管重塑的促炎生物标志物，在 CKD5-HD 和 AF 中升高，但在同时患有 AF 和 CKD5-HD 的患者中尚未得到评估。本研究旨在分析同时患有 AF 和 CKD5-HD 的患者循环中炎症和血栓形成生物标志物的水平。通过夹心酶联免疫吸附测定法测量了 CKD5-HD 患者（n=96）、AF 患者（n=38）和对照组（n=50）的血浆 Ang-2 水平。与单独 CKD5-HD 相比，同时患有 AF 和 CKD5-HD 的患者的 Ang-2 水平明显升高，分别为（13.05±1.56）ng/mL 比（9.57±0.71）ng/mL（ =.00169）；与单独 AF 相比，分别为（13.05±1.56）ng/mL 比（2.48±0.57）ng/mL（ <.0001）。这项研究的结果表明，AF 与 CKD5-HD 共存时存在 Ang-2 的附加效应，这可能有助于在该患者人群中检测 AF。
