健康双胞胎的脑干脑桥灰质体积、幸福感和适应力之间呈负相关。
A negative association between brainstem pontine grey-matter volume, well-being and resilience in healthy twins.
机构信息
From the Neuroscience Research Australia, Randwick, Australia (Gatt, Burton, Schofield); the School of Psychology, University of New South Wales, Sydney, Australia (Gatt, Burton); the Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia (Routledge, Korgaonkar, Harris); the Queensland Institute of Medical Research, Brisbane, Queensland, Australia (Grasby); the Discipline of Psychiatry, School of Medicine, University of Sydney, New South Wales, Australia (Korgaonkar, Harris, Williams); the Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre, University of Sydney, Australia, and the Department of Radiology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia (Grieve); the School of Medical Sciences, University of New South Wales, Sydney, Australia (Schofield); the School of Psychology, Flinders University, Bedford Park, South Australia, Australia, and Brain Clinics Australia, Unley, South Australia (Clark); the Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, California, United States of America (Williams); and the MIRECC VISN21, VA Palo Alto Health Care System, California, United States of America (Williams).
出版信息
J Psychiatry Neurosci. 2018 Nov 1;43(6):386-395. doi: 10.1503/jpn.170125.
BACKGROUND
Associations between well-being, resilience to trauma and the volume of grey-matter regions involved in affective processing (e.g., threat/reward circuits) are largely unexplored, as are the roles of shared genetic and environmental factors derived from multivariate twin modelling.
METHODS
This study presents, to our knowledge, the first exploration of well-being and volumes of grey-matter regions involved in affective processing using a region-of-interest, voxel-based approach in 263 healthy adult twins (60% monozygotic pairs, 61% females, mean age 39.69 yr). To examine patterns for resilience (i.e., positive adaptation following adversity), we evaluated associations between the same brain regions and well-being in a trauma-exposed subgroup.
RESULTS
We found a correlated effect between increased well-being and reduced grey-matter volume of the pontine nuclei. This association was strongest for individuals with higher resilience to trauma. Multivariate twin modelling suggested that the common variance between the pons volume and well-being scores was due to environmental factors.
LIMITATIONS
We used a cross-sectional sample; results need to be replicated longitudinally and in a larger sample.
CONCLUSION
Associations with altered grey matter of the pontine nuclei suggest that basic sensory processes, such as arousal, startle, memory consolidation and/or emotional conditioning, may have a role in well-being and resilience.
背景
幸福感、创伤后适应力以及涉及情感处理的灰质区域（例如，威胁/奖励回路）的体积之间的关联在很大程度上尚未得到探索，而从多变量双胞胎模型得出的共享遗传和环境因素的作用也是如此。
方法
本研究使用基于感兴趣区域的体素方法，在 263 名健康成年双胞胎（60％为同卵双胞胎，61％为女性，平均年龄 39.69 岁）中，首次探索了幸福感和涉及情感处理的灰质区域的体积。为了研究适应力（即逆境后的积极适应）的模式，我们评估了相同大脑区域与创伤后亚组的幸福感之间的关联。
结果
我们发现，幸福感的提高与脑桥核灰质体积的减少之间存在相关效应。对于对创伤具有更高适应力的个体，这种关联最强。多变量双胞胎模型表明，桥体积和幸福感评分之间的共同方差是由环境因素引起的。
局限性
我们使用了横断面样本；结果需要在更大的样本中进行纵向和重复验证。
结论
与脑桥核灰质改变相关的关联表明，基本的感觉过程，如觉醒、惊吓、记忆巩固和/或情绪调节，可能在幸福感和适应力中起作用。
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