State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China.
Org Biomol Chem. 2018 Nov 14;16(44):8434-8445. doi: 10.1039/c8ob02157k.
Molecular photoswitches are a class of chemical structures that can readily isomerize between distinct geometries upon irradiation with light. Molecular photoswitches are utilized to control protein structure and function with temporal and spatial precision. In this review, we summarize the recent progress in the development of azobenzene-based molecular photoswitches and their applications in the photocontrol of protein structure and function. For clarity of discussion, we divide the known photoswitchable proteins into different categories: protein motifs, ion channels, receptors, and enzymes. Basic approaches and considerations for the structure-guided design of photoswitchable ligands are discussed. The applications and limitations of current photoswitches are also discussed.
分子光开关是一类化学结构，在光照射下可以很容易地在不同的几何形状之间互变。分子光开关用于以时间和空间精度控制蛋白质结构和功能。在这篇综述中，我们总结了基于偶氮苯的分子光开关的最新进展及其在蛋白质结构和功能的光控中的应用。为了讨论的清晰性，我们将已知的光可切换蛋白质分为不同的类别：蛋白质基序、离子通道、受体和酶。讨论了基于结构的光可切换配体设计的基本方法和考虑因素。还讨论了当前光开关的应用和局限性。
