1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
2 Department of Molecular Biosciences, University of California Davis, Davis, CA, USA.
J Cereb Blood Flow Metab. 2019 Feb;39(2):367-370. doi: 10.1177/0271678X18811277. Epub 2018 Oct 30.
Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells' regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
中风是美国和全球范围内导致死亡和残疾的主要原因，目前治疗选择有限。在这里，我们讨论了线粒体在干细胞介导的中风脑保护中的关键作用，强调了从干细胞中删除线粒体可消除细胞的再生能力这一概念。应用创新方法，包括生成线粒体缺失的干细胞以及抑制线粒体功能的药理学方法，可能阐明将健康线粒体转移到缺血细胞的机制，从而为中风和其他受线粒体功能障碍影响的脑部疾病的病理和治疗提供重要见解。
