Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
J Trauma Stress. 2018 Dec;31(6):927-932. doi: 10.1002/jts.22339. Epub 2018 Oct 30.
In the present study, we sought to replicate recent findings of Polimanti et al. (2017), who conducted a genome-wide gene-by-environment interaction study (GEWIS) and identified a gene-by-trauma interaction that predicts alcohol misuse among African Americans. Consistent with the findings published by Polimanti and colleagues, results of the current study demonstrated an interaction effect, b = 0.41, of trauma exposure and rs1729578 in the intron of PRKG1 on alcohol misuse in a subsample of ancestral African Americans. The minor allele (rs1729578*C) was positively associated with increased alcohol use disorder symptoms in trauma-exposed subjects and negatively associated in non-trauma-exposed subjects. This effect, however, was only significant for one out of three alcohol outcome measures we investigated, suggesting the interaction may be most salient when predicting higher severity of alcohol misuse. Additionally, the effect did not remain significant after we accounted for testing the effect on three different outcome variables. Also in line with the original study, the gene-by-environment effect was not demonstrated among the ancestral European subsample. The findings suggest this gene variant may increase an individual's susceptibility to environmental influences, both adverse and supportive.
在本研究中，我们试图复制 Polimanti 等人（2017 年）最近的研究结果，他们进行了一项全基因组基因-环境交互作用研究（GEWIS），并发现了一个基因-创伤交互作用，可预测非裔美国人的酒精滥用。与 Polimanti 及其同事发表的研究结果一致，本研究的结果表明，在一个非洲裔美国人祖先的亚样本中，创伤暴露和 PRKG1 内含子中的 rs1729578 与酒精滥用之间存在交互作用效应，b = 0.41。在创伤暴露的受试者中，次要等位基因（rs1729578*C）与增加的酒精使用障碍症状呈正相关，而在非创伤暴露的受试者中则呈负相关。然而，这种效应仅在我们研究的三种酒精结局测量中的一种中显著，表明当预测更高严重程度的酒精滥用时，这种相互作用可能最为明显。此外，在考虑对三个不同的结局变量进行检验后，该效应不再显著。与原始研究一致，该基因-环境效应在祖先欧洲亚样本中也没有表现出来。这些发现表明，这种基因变异可能增加个体对环境影响的易感性，包括不利和有利的影响。
