Werner Kimberly B, Sartor Carolyn E, McCutcheon Vivia V, Grant Julia D, Nelson Elliot C, Heath Andrew C, Bucholz Kathleen K
George Warren Brown School of Social Work, Washington University, St. Louis, Missouri.
Alcohol Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Alcohol Clin Exp Res. 2016 Nov;40(11):2401-2408. doi: 10.1111/acer.13220. Epub 2016 Sep 22.
The aims of this study were to (i) characterize racial differences in alcohol involvement and (ii) examine the risk conferred by specific trauma exposures and posttraumatic stress disorder (PTSD) for different stages of alcohol involvement in European American (EA) and African American (AA) women.
Data are from the Missouri Adolescent Female Twins Study (N = 3,787, 14.6% AA; mean age at most recent interview = 24.5 [SD 2.8]). Trauma exposures (e.g., sexual abuse [SA], physical abuse [PA], witnessing another person being killed or injured, experiencing an accident, and experiencing a disaster) were modeled as time-varying predictors of alcohol initiation, transition to first alcohol use disorder (AUD) symptom, and transition to AUD diagnosis using Cox proportional hazards regression while taking into account other substance involvement, parental characteristics, and commonly co-occurring psychiatric disorders.
In EA women only, SA was associated with alcohol initiation prior to the age of 14, PA predicted transition from initiation to first AUD symptom, and PA, witnessing injury or death, and SA predicted transition to AUD diagnosis. No association was discovered between trauma exposures or PTSD for any stage of alcohol involvement in AA women.
Results reveal trauma experiences as important contributors to all stages of alcohol involvement in EA women only, with different trauma types conferring risk for each stage of alcohol involvement. PTSD was not revealed as a significant predictor of AUD in EA or AA women, suggesting trauma, independent of PTSD, directly contributes to alcohol involvement. Findings highlight the importance of considering racial differences when developing etiologic models of the association of traumatic experiences with alcohol involvement.
本研究的目的是:(i)描述酒精使用方面的种族差异;(ii)研究特定创伤暴露及创伤后应激障碍(PTSD)对欧美裔(EA)和非裔美国(AA)女性酒精使用不同阶段所带来的风险。
数据来自密苏里青少年女性双胞胎研究(N = 3787,14.6%为非裔美国人;最近一次访谈时的平均年龄 = 24.5[标准差2.8])。创伤暴露(如性虐待[SA]、身体虐待[PA]、目睹他人被杀或受伤、经历事故和经历灾难)被建模为酒精开始使用、向首次酒精使用障碍(AUD)症状转变以及向AUD诊断转变的时变预测因素,采用Cox比例风险回归,同时考虑其他物质使用情况、父母特征和常见的共病精神障碍。
仅在欧美裔女性中,性虐待与14岁之前开始饮酒有关,身体虐待预示着从开始饮酒到首次出现AUD症状的转变,而身体虐待、目睹受伤或死亡以及性虐待则预示着向AUD诊断的转变。在非裔美国女性的任何酒精使用阶段,均未发现创伤暴露或PTSD与之存在关联。
结果显示,创伤经历仅是欧美裔女性酒精使用各阶段的重要促成因素,不同类型的创伤会给酒精使用的每个阶段带来风险。创伤后应激障碍在欧美裔或非裔美国女性中均未被发现是酒精使用障碍的显著预测因素,这表明创伤独立于创伤后应激障碍,直接导致酒精使用。研究结果凸显了在建立创伤经历与酒精使用关联的病因模型时考虑种族差异的重要性。