Catholic University of Sacred Heart, Rome, Italy.
Dermatol Ther. 2018 Nov;31(6):e12690. doi: 10.1111/dth.12690. Epub 2018 Oct 30.
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%), urea-containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea-based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti-inflammatory and anti-fungal drugs, due to its activity as a penetration enhancer.
屏障功能的改变与许多皮肤疾病有关，包括干燥症、特应性皮炎和银屑病。尿素是皮肤天然保湿因子的组成部分，在保持皮肤水分和完整性方面起着重要作用。多项研究已经在临床环境中调查了尿素的作用。在这里，我们总结了关于尿素在维持健康皮肤和治疗皮肤疾病方面的临床证据。在较低剂量（≤10%）下，含尿素的局部制剂用作皮肤保湿剂，而在较高浓度（>10%尿素）下，基于尿素的制剂发挥角质松解作用。由于尿素具有渗透增强作用，它在与抗炎和抗真菌药物的联合治疗中也很有用。
