Jawed Inshal, Umair Abdul Qadir Muhammad, Farwa Umm E, Alam Farah, Bakhtawar Fatima Fasiha, Khan Hina, Kumar Karmani Vikash, Javaid Maham, Raja Sandesh, Khuzzaim Khan Muhammad, Raja Adarsh, Khanal Anuva
Department of Dermatology, Dow University of Health Sciences, Karachi, Pakistan.
Department of Dermatology, Jinnah Sindh Medical University, Karachi, Pakistan.
Ann Med Surg (Lond). 2025 Jan 9;87(1):276-284. doi: 10.1097/MS9.0000000000002797. eCollection 2025 Jan.
The urea composition has a profound effect on skin disorders, specifically xerosis, desquamation, and scaling, which are some of the main concerns of the current health industry. The application of urea is relatable and more bioactive than alternate treatments. The objective of this systematic review was to evaluate the effectiveness of topically applied urea in the treatment of ichthyosis, psoriasis, and other dermatologic conditions.
Research articles were retrieved through electronic databases, including Google Scholar, PubMed, EMBASE, Elsevier, and Sage, selected based on the provision of online free literature from its inception till November 2023. The significant findings were skin dryness, transepidermal water loss (TEWL), and eczema.
A total of 1826 studies have been found, of which 31 were selected based on inclusion criteria. The primary reason for the exclusion of the studies was the application of urea as a control. All in vivo studies disclosed the effectiveness of urea treatment separately or in addition to another compound on skin conditions. The selected studies have reported findings related to the improvement in xerosis, erythema, scaling, and reduction in TEWL.
According to the in-depth review of the research articles, the application of urea has a tremendous effect on different skin diseases. Still, its role as monotherapy is overlooked due to the presence of more susceptible alternate products that need to be addressed. However, in the future, the evaluation of the effects of treatment containing urea with antibiotics on skin diseases would be more beneficial for practical knowledge.
尿素成分对皮肤疾病有深远影响，特别是皮肤干燥、脱屑和鳞屑，这些是当前健康行业的一些主要关注点。与其他替代治疗方法相比，尿素的应用更具相关性且生物活性更强。本系统评价的目的是评估局部应用尿素治疗鱼鳞病、银屑病和其他皮肤病的有效性。
通过电子数据库检索研究文章，包括谷歌学术、PubMed、EMBASE、爱思唯尔和Sage，这些数据库是根据从其创立到2023年11月提供在线免费文献来选择的。重要发现包括皮肤干燥、经表皮水分流失（TEWL）和湿疹。
共检索到1826项研究，其中31项根据纳入标准被选中。排除这些研究的主要原因是将尿素用作对照。所有体内研究均单独或与另一种化合物联合揭示了尿素治疗对皮肤状况的有效性。所选研究报告了与皮肤干燥、红斑、鳞屑改善以及TEWL降低相关的结果。
根据对研究文章的深入综述，尿素的应用对不同皮肤病有巨大影响。然而，由于存在更易获得的替代产品，其作为单一疗法的作用被忽视了，这一点需要解决。不过，未来评估含尿素与抗生素的治疗对皮肤病的影响将对实际知识更有益。
